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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CEFEPIME

CEFEPIME


ATC J01DE01
ATC J01RA06

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
CEPHALOSPORINS

INJECTION INTRAVENOUS

Cmax 340.7 MICROMOLAR

F 82 PERCENT (IM)

VD 18 LITER

PPB 20 PERCENT

Cl 7.2 LITER / HOUR

HT 2 HOUR

SOLUBILITY HIGHLY SOLUBLE IN WATER

PENICILLIN-BINDING PROTEIN

PDB 5OJ0 (PENICILLIN-BINDING PROTEIN 2X (PBP2X) FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH CEFEPIME)

LIGAND CODE = 9WT (link to the list of PDB complexes)

Download experimental 3D coordinates of 9WT with added hydrogens

BACTERIAL PENICILLIN-BINDING PROTEIN INHIBITOR CHEMBL2354204 BACTERIAL PENICILLIN-BINDING PROTEIN P02918 PENICILLIN-BINDING PROTEIN 1A BACTERIA ENZYME PROTEASE SERINE UNCLASSIFIEDANSM (in French)

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SIDER side effects

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BindingDB
DrugBank



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