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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CEFUROXIME (is an active metabolite)
| CEFUROXIME |
ANTIINFECTIVES | INTRAMUSCULAR INTRAVENOUS INJECTION | Cmax 32 MICROMOLAR (1 GRAM) Tmax 2.5 HOUR VD 9.7 LITER (65 KILOGRAM) PPB 50 PERCENT Cl 8.6 LITER / HOUR (65 KILOGRAM) HT 1.3 HOUR | PENICILLIN-BINDING PROTEINS 1A/1B PDB 4KOV (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFUROXIME) LIGAND CODE = KOV (link to the list of PDB complexes) Download experimental 3D coordinates of KOV with added hydrogens | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CEFUROXIME AXETIL (has an active metabolite)
| CEFUROXIME AXETIL |
ANTIINFECTIVES | ORAL | PENICILLIN-BINDING PROTEINS 1A/1B | Bacterial penicillin-binding protein UNIPROT P02918 mrcA more at DrugCentral | EMA | ||||
