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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHOTREXATE
| METHOTREXATE | ANTINEOPLASTIC | ORAL INJECTION SUBCUTANEOUS INTRAVENOUS | Cmax 2.3 MICROMOLAR Tmax 1.5 HOUR F 60 PERCENT VD 39 LITER (65 KILOGRAM) PPB 50 PERCENT Cl 8.2 LITER / HOUR (65 KILOGRAM) HT 7.5 HOUR | DIHYDROFOLATE REDUCTASE PDB 5X66 (HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTREXATE) LIGAND CODE = MTX (link to the list of PDB complexes) Download experimental 3D coordinates of MTX with added hydrogens | Dihydrofolate reductase UNIPROT P00374 DHFR more at DrugCentral | EMA | |||
