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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CEFOTAXIME

CEFOTAXIME


ATC J01DD01
ATC J01DD51

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
CEPHALOSPORINS

INJECTION

Cmax 471 MICROMOLAR (2 GRAM)

VD 12.3 LITER (65 KILOGRAM)

PPB 40 PERCENT

Cl 10.5 LITER / HOUR (65 KILOGRAM)

HT 1 HOUR

PENICILLIN-BINDING PROTEINS 1A/1B
PENICILLIN-BINDING PROTEIN 3

PDB 4PM7 (CRYSTAL STRUCTURE OF CTX-M-14 S70G:S237A IN COMPLEX WITH CEFOTAXIME AT 1.29 ANGSTROMS RESOLUTION)

LIGAND CODE = CE3 (link to the list of PDB complexes)

Download experimental 3D coordinates of CE3 with added hydrogens

BACTERIAL PENICILLIN-BINDING PROTEIN INHIBITOR CHEMBL2354204 BACTERIAL PENICILLIN-BINDING PROTEIN P02918 PENICILLIN-BINDING PROTEIN 1A BACTERIA ENZYME PROTEASE SERINE UNCLASSIFIEDANSM (in French)

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