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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CEFOTAXIME DISCONTINUED
| CEFOTAXIME | ANTIINFECTIVES | INJECTION | Cmax 471 MICROMOLAR (2 GRAM) VD 12.3 LITER (65 KILOGRAM) PPB 40 PERCENT Cl 10.5 LITER / HOUR (65 KILOGRAM) HT 1 HOUR | PENICILLIN-BINDING PROTEINS 1A/1B PENICILLIN-BINDING PROTEIN 3 PDB 4PM7 (CRYSTAL STRUCTURE OF CTX-M-14 S70G:S237A IN COMPLEX WITH CEFOTAXIME AT 1.29 ANGSTROMS RESOLUTION) LIGAND CODE = CE3 (link to the list of PDB complexes) Download experimental 3D coordinates of CE3 with added hydrogens | Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI -- Penicillin-binding protein 1A UNIPROT P02918 mrcA more at DrugCentral | EMA | |||
