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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CEFOXITIN

CEFOXITIN


ATC J01DC01

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
CEPHALOSPORINS
INHIBITION OF CELL WALL SYNTHESIS

INJECTION INTRAVENOUS

Cmax 257 MICROMOLAR (1 GRAM)

VD 11 LITER (65 KILOGRAM)

PPB 27 PERCENT

Cl 14 LITER / HOUR (65 KILOGRAM)

HT 0.81 HOUR

PENICILLIN-BINDING PROTEINS 1A/1B
BETA-LACTAMASE
BETA-LACTAMASE CTX-M-9A

PDB 4KOW (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFOXITIN)

LIGAND CODE = CFX (link to the list of PDB complexes)

Download experimental 3D coordinates of CFX with added hydrogens

BACTERIAL PENICILLIN-BINDING PROTEIN INHIBITOR CHEMBL2354204 BACTERIAL PENICILLIN-BINDING PROTEIN P02918 PENICILLIN-BINDING PROTEIN 1A BACTERIA ENZYME PROTEASE SERINE UNCLASSIFIEDANSM (in French)

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