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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DAUNORUBICIN (has an active metabolite)
| DAUNORUBICIN | NATURAL MOLECULE (link) ANTINEOPLASTIC | INJECTION INTRAVENOUS | VD 1006 LITER Cl 14 LITER / HOUR HT 18.5 HOUR | TOPOISOMERASE II DNA MULTIDRUG RESISTANCE PROTEIN 1 POLYMERASE PDB 3TVB (A HIGHLY SYMMETRIC DNA G-4 QUADRUPLEX, DRUG COMPLEX) LIGAND CODE = DM1 (link to the list of PDB complexes) Download experimental 3D coordinates of DM1 with added hydrogens | DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A more at DrugCentral | EMA | |||
