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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DOXORUBICIN
| DOXORUBICIN | ANTINEOPLASTIC | INJECTION | Cmax 11.4 MICROMOLAR (PMID18621671) VD 1430 LITER (65 KILOGRAM) PPB 72 PERCENT Cl 58.5 LITER / HOUR (65 KILOGRAM) HT 32 HOUR | TOPOISOMERASE II DNA PDB 1DA9 (ANTHRACYCLINE-DNA INTERACTIONS AT UNFAVOURABLE BASE BASE-PAIR TRIPLET-BINDING SITES: STRUCTURES OF D(CGGCCG), DAUNOMYCIN AND D(TGGCCA), ADRIAMYCIN COMPL) LIGAND CODE = DM2 (link to the list of PDB complexes) Download experimental 3D coordinates of DM2 with added hydrogens | DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A more at DrugCentral | EMA | |||
