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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIFAMPIN
| RIFAMPIN |
ANTIINFECTIVES | ORAL INJECTION | Cmax 38.9 MICROMOLAR (600 MILLIGRAM) Tmax 2.5 HOUR VD 63 LITER (65 KILOGRAM) PPB 80 PERCENT Cl 13.6 LITER / HOUR (65 KILOGRAM) HT 3.6 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | DNA-DEPENDENT RNA POLYMERASE ADP-RIBOSYL TRANSFERASE PDB 2HW2 (CRYSTAL STRUCTURE OF RIFAMPIN ADP-RIBOSYL TRANSFERASE IN COMPLEX WITH RIFAMPIN) LIGAND CODE = RFP (link to the list of PDB complexes) Download experimental 3D coordinates of RFP with added hydrogens | DNA-directed RNA polymerase subunit beta UNIPROT P0A8V2 rpoB more at DrugCentral | EMA | |||
