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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RIFAMPIN

RIFAMPIN


ATC J04AB02
ATC J04AM02
ATC J04AM07
ATC J04AM05
ATC J04AM06

ANTIINFECTIVES
TUBERCULOSTATIC
ANTIFUNGAL
ANTIBIOTIC
ANTIBACTERIAL
LEPROSTATIC
INHIBIOR OF DNA-DEPENDENT RNA POLYMERASE ACTIVITY IN MYCOBACTERIUM TUBERCULOSIS ORGANISMS (DOES NOT INHIBIT THE MAMMALIAN ENZYME)

ORAL INJECTION

Cmax 38.9 MICROMOLAR (600 MILLIGRAM)

VD 63 LITER (65 KILOGRAM)

PPB 80 PERCENT

Cl 13.6 LITER / HOUR (65 KILOGRAM)

HT 3.6 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

DNA-DEPENDENT RNA POLYMERASE
ADP-RIBOSYL TRANSFERASE

PDB 2HW2 (CRYSTAL STRUCTURE OF RIFAMPIN ADP-RIBOSYL TRANSFERASE IN COMPLEX WITH RIFAMPIN)

LIGAND CODE = RFP (link to the list of PDB complexes)

Download experimental 3D coordinates of RFP with added hydrogens

BACTERIAL DNA-DIRECTED RNA POLYMERASE INHIBITOR CHEMBL2364672 BACTERIAL DNA-DIRECTED RNA POLYMERASE P0A8T7 DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' BACTERIA ENZYME TRANSFERASEANSM (in French)

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