e-Drug3D
923
cas 126544-47-6
CLASS
RESPIRATORY
ANTIINFLAMMATORY
ANTI-ALLERGIC AGENTS
GLUCOCORTICOIDS
ROUTE (list)
INHALATION NASAL
PK parameters
F 22 PERCENT
VD 188 LITER (65 KILOGRAM)
Cl 152 LITER / HOUR
PPB 99 PERCENT
t1/2 0.71 HOUR
TARGET CORTICOSTEROID-BINDING GLOBULIN
Glucocorticoid receptor UNIPROT P04150 NR3C1
Formula:
C32H44O7
Calculated chemical properties:
MW 540.67
NB_atoms 39
XLogP 4.70
PSA 86.953
NB_HD 1
NB_HA 7
fsp3 0.78
Lipinski(0=no;1=yes) 0
NB_atoms 39
XLogP 4.70
PSA 86.953
NB_HD 1
NB_HA 7
fsp3 0.78
Lipinski(0=no;1=yes) 0
FDA
NDA 022004 (label) INN (CICLESONIDE) OMNARIS (AZURITY) APPROVAL= AP YEAR= 2006 NEWMOLECULARENTITY
NDA 022124 (label) INN (CICLESONIDE) OMNARIS (NYCOMED US INC) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 021658 (label) INN (CICLESONIDE) ALVESCO (AZURITY) APPROVAL= AP YEAR= 2008
NDA 202129 (label) INN (CICLESONIDE) ZETONNA (AZURITY) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 022004 (label) INN (CICLESONIDE) OMNARIS (AZURITY) APPROVAL= AP YEAR= 2006 NEWMOLECULARENTITY
NDA 022124 (label) INN (CICLESONIDE) OMNARIS (NYCOMED US INC) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 021658 (label) INN (CICLESONIDE) ALVESCO (AZURITY) APPROVAL= AP YEAR= 2008
NDA 202129 (label) INN (CICLESONIDE) ZETONNA (AZURITY) APPROVAL= AP YEAR= 2012 DISCONTINUED
e-Drug3D
1642
cas 161115-59-9
CLASS
RESPIRATORY
ANTIINFLAMMATORY
ANTI-ALLERGIC AGENTS
GLUCOCORTICOIDS
ROUTE (list)
-
PK parameters
F 63 PERCENT
Tmax 1.04 HOUR
VD 786 LITER (65 KILOGRAM)
Cl 228 LITER / HOUR
PPB 99 PERCENT
t1/2 6.5 HOUR
TARGET CORTICOSTEROID-BINDING GLOBULIN
PDB
4UDD (GR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE)
Ligand code = CV7 (link to the list of PDB complexes)
Download experimental 3D coordinates of CV7 with added hydrogens
Glucocorticoid receptor UNIPROT P04150 NR3C1
Formula:
C28H38O6
Calculated chemical properties:
MW 470.58
NB_atoms 34
XLogP 3.50
PSA 82.504
NB_HD 2
NB_HA 6
fsp3 0.79
Lipinski(0=no;1=yes) 1
NB_atoms 34
XLogP 3.50
PSA 82.504
NB_HD 2
NB_HA 6
fsp3 0.79
Lipinski(0=no;1=yes) 1
FDA
-
-