e-Drug3D

824

cas 67-97-0

CLASS

METABOLISM
VITAMIN D3
ANTIARTHRITIC
ANTIHYPOCALCEMIC AGENTS
ANTIHYPOPARATHYROID AGENTS
BONE DENSITY CONSERVATION AGENTS
SECOSTEROL

ROUTE (list)

INTRAVENOUS ORAL

PK parameters

Tmax 10.6 HOUR
t1/2 14 HOUR

MW 384.62
NB_atoms 28
XLogP 7.62
PSA 21.28
NB_HD 1
NB_HA 1
fsp3 0.78
Lipinski(0=no;1=yes) 0

FDA
NDA 021163 (label) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) INFUVITE ADULT (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2000
NDA 021265 (label) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) INFUVITE PEDIATRIC (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2001
NDA 021559 (label) INN (CHOLECALCIFEROL) INFUVITE ADULT (SANDOZ INC) APPROVAL= AP YEAR= 2003 OBSOLETE
NDA 021646 (label) INN (CHOLECALCIFEROL) INFUVITE PEDIATRIC PHARMACY BULK PACKAGE (SANDOZ INC) APPROVAL= AP YEAR= 2004 OBSOLETE
NDA 021762 (label) INN (ALENDRONATE SODIUM ; CHOLECALCIFEROL) FOSAMAX PLUS D (ORGANON LLC) APPROVAL= AP YEAR= 2005
NDA 210273 (pdf not found) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) MULTIPLE VITAMINS INJECTION ADULT (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210456 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC PHARMACY BULK PACKAGE (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210671 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210672 (pdf not found) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) MULTIPLE VITAMINS INJECTION ADULT (APOTEX) APPROVAL= AP YEAR= 2026

e-Drug3D

480

cas 32222-06-3

CLASS

METABOLISM
ANTIHYPOCALCEMIC AGENTS
BONE DENSITY CONSERVATION AGENTS
VITAMINS (VITAMIN D)

ROUTE (list)

ORAL INJECTION TOPICAL

PK parameters

Tmax 4.5 HOUR
PPB 99.9 PERCENT
t1/2 6.5 HOUR

TARGET VITAMIN D3 RECEPTOR

PDB
1DB1 (CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D)

Ligand code = VDX (link to the list of PDB complexes)

Download experimental 3D coordinates of VDX with added hydrogens

MW 416.62
NB_atoms 30
XLogP 5.70
PSA 62.227
NB_HD 3
NB_HA 3
fsp3 0.78
Lipinski(0=no;1=yes) 0

FDA
NDA 018044 (pdf not found) INN (CALCITRIOL) ROCALTROL (ESJAY PHARMA) APPROVAL= AP YEAR= 1978
NDA 018874 (label) INN (CALCITRIOL) CALCIJEX (ABBVIE) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 021068 (label) INN (CALCITRIOL) ROCALTROL (ESJAY PHARMA) APPROVAL= AP YEAR= 1998
NDA 075765 (pdf not found) INN (CALCITRIOL) CALCITRIOL (TEVA) APPROVAL= AP YEAR= 2001
NDA 075836 (pdf not found) INN (CALCITRIOL) CALCITRIOL (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075746 (pdf not found) INN (CALCITRIOL) CALCITRIOL (AM REGENT) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 075766 (pdf not found) INN (CALCITRIOL) CALCITRIOL (FRESENIUS MEDCL) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 075823 (pdf not found) INN (CALCITRIOL) CALCITRIOL (TEVA PARENTERAL) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076206 (pdf not found) INN (CALCITRIOL) CALCITRIOL (ROCKWELL MEDCL) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076242 (pdf not found) INN (CALCITRIOL) CALCITRIOL (HIKMA) APPROVAL= AP YEAR= 2003
NDA 075816 (pdf not found) INN (CALCITRIOL) CALCITRIOL (HOSPIRA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076917 (pdf not found) INN (CALCITRIOL) CALCITRIOL (HIKMA) APPROVAL= AP YEAR= 2006
NDA 077102 (pdf not found) INN (CALCITRIOL) CALCITRIOL (SAGENT PHARMS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 078066 (pdf not found) INN (CALCITRIOL) CALCITRIOL (LONG GROVE PHARMS) APPROVAL= AP YEAR= 2008
NDA 022087 (label) INN (CALCITRIOL) VECTICAL (GALDERMA LABS LP) APPROVAL= AP YEAR= 2009
NDA 091174 (pdf not found) INN (CALCITRIOL) CALCITRIOL (BIONPHARMA) APPROVAL= AP YEAR= 2013
NDA 091356 (pdf not found) INN (CALCITRIOL) CALCITRIOL (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2014
NDA 203289 (pdf not found) INN (CALCITRIOL) CALCITRIOL (AMNEAL PHARMS) APPROVAL= AP YEAR= 2017
NDA 209798 (pdf not found) INN (CALCITRIOL) CALCITRIOL (RISING) APPROVAL= AP YEAR= 2018
NDA 204556 (pdf not found) INN (CALCITRIOL) CALCITRIOL (SUN PHARM) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211030 (pdf not found) INN (CALCITRIOL) CALCITRIOL (GLAND) APPROVAL= AP YEAR= 2020
NDA 203973 (pdf not found) INN (CALCITRIOL) CALCITRIOL (ANDA REPOSITORY) APPROVAL= AP YEAR= 2023
NDA 219796 (pdf not found) INN (CALCITRIOL) CALCITRIOL (HUMANWELL PURACAP) APPROVAL= AP YEAR= 2026