e-Drug3D

81

cas 599-79-1

CLASS

METABOLISM
ANTIINFLAMMATORY
TREATMENT OF MILD TO MODERATE ULCERATIVE COLITIS
INTERFERENCE WITH TETRAHYDROBIOPTERIN METABOLISM (BINDS SEPIAPTERIN REDUCTASE (SPR)(PMID21499265))

ROUTE (list)

ORAL

PK parameters

F 15 PERCENT
Tmax 6 HOUR
Cmax 15 MICROMOLAR
VD 7.5 LITER
Cl 1 LITER / HOUR
PPB 99.3 PERCENT
t1/2 7.6 HOUR

MW 397.39
NB_atoms 28
XLogP 0.47
PSA 124.072
NB_HD 2
NB_HA 9
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 088052 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089339 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (SUPERPHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 007073 (label) INN (SULFASALAZINE) AZULFIDINE (PFIZER) APPROVAL= AP YEAR= 1950
NDA 080197 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (CHARTWELL) APPROVAL= AP YEAR= 1973
NDA 083450 (pdf not found) INN (SULFASALAZINE) S.A.S.-500 (SOLVAY) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084964 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (WATSON LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085828 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (WATSON LABS) APPROVAL= AP YEAR= 1977
NDA 018605 (pdf not found) INN (SULFASALAZINE) AZULFIDINE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 086983 (pdf not found) INN (SULFASALAZINE) AZULFIDINE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1980 OBSOLETE
NDA 087197 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 086184 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 089590 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 020465 (label) INN (SULFASALAZINE) AZULFIDINE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1996 NEWAPPLICATION
NDA 021243 (label) INN (SULFASALAZINE) AZULFIDINE EN-TABS (PHARMACIA UPJOHN) APPROVAL= AP YEAR= 2000 NEWAPPLICATION
NDA 040349 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (NUVO PHARMS INC) APPROVAL= AP YEAR= 2002
NDA 075339 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (NUVO PHARMS INC) APPROVAL= AP YEAR= 2002
NDA 219046 (pdf not found) INN (SULFASALAZINE) SULFASALAZINE (RISING) APPROVAL= AP YEAR= 2025

e-Drug3D

1

cas 144-83-2

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL

ROUTE (list)

ORAL

PK parameters

-

PDB
4HWK (CRYSTAL STRUCTURE OF HUMAN SEPIAPTERIN REDUCTASE IN COMPLEX WITH SULFAPYRIDINE)

Ligand code = SFY (link to the list of PDB complexes)

Download experimental 3D coordinates of SFY with added hydrogens

MW 249.30
NB_atoms 17
XLogP 1.46
PSA 77.23
NB_HD 3
NB_HA 5
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 000159 (pdf not found) INN (SULFAPYRIDINE) SULFAPYRIDINE (LILLY) APPROVAL= AP YEAR= 1939 DISCONTINUED

e-Drug3D

1399

cas 89-57-6

CLASS

METABOLISM
ANTIINFLAMMATORY
IT IS POSSIBLE THAT IT DIMINISHES INFLAMMATION BY BLOCKING PRODUCTION OF ARACHIDONIC ACID METABOLITES
INHIBITOR OF CYCLOOXYGENASE
MAINTENANCE OF REMISSION OF ULCERATIVE COLITIS

ROUTE (list)

RECTAL ORAL

PK parameters

F 28 PERCENT
Tmax 6 HOUR
Cmax 17.6 MICROMOLAR
VD 21.4 LITER (65 KILOGRAM)
Cl 36.2 LITER / HOUR (65 KILOGRAM)
PPB 43 PERCENT
t1/2 1 HOUR

MW 152.13
NB_atoms 11
XLogP -0.66
PSA 77.875
NB_HD 3
NB_HA 4
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 019618 (label) INN (MESALAMINE) ROWASA (MYLAN SPECIALITY LP) APPROVAL= AP YEAR= 1987
NDA 019919 (pdf not found) INN (MESALAMINE) ROWASA (MEDA PHARMS) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 019651 (label) INN (MESALAMINE) ASACOL (APIL) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 020049 (label) INN (MESALAMINE) PENTASA (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 1993
NDA 021252 (label) INN (MESALAMINE) CANASA (ABBVIE) APPROVAL= AP YEAR= 2001
NDA 076751 (pdf not found) INN (MESALAMINE) MESALAMINE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2004
NDA 076841 (pdf not found) INN (MESALAMINE) MESALAMINE (G AND W LABS INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 022000 (label) INN (MESALAMINE) LIALDA (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2007
NDA 021830 (label) INN (MESALAMINE) ASACOL HD (ABBVIE) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 022301 (label) INN (MESALAMINE) APRISO (SALIX) APPROVAL= AP YEAR= 2008
NDA 204412 (label) INN (MESALAMINE) DELZICOL (ABBVIE) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204354 (label) INN (MESALAMINE) MESALAMINE (QUAGEN) APPROVAL= AP YEAR= 2015
NDA 091640 (label) INN (MESALAMINE) MESALAMINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 203286 (pdf not found) INN (MESALAMINE) MESALAMINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 203817 (pdf not found) INN (MESALAMINE) MESALAMINE (ACTAVIS LABS FL) APPROVAL= AP YEAR= 2018
NDA 203574 (pdf not found) INN (MESALAMINE) MESALAMINE (MYLAN) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 202065 (pdf not found) INN (MESALAMINE) MESALAMINE (SANDOZ) APPROVAL= AP YEAR= 2019
NDA 208362 (pdf not found) INN (MESALAMINE) MESALAMINE (J MOLNER) APPROVAL= AP YEAR= 2019
NDA 207448 (pdf not found) INN (MESALAMINE) MESALAMINE (RISING) APPROVAL= AP YEAR= 2019
NDA 207873 (pdf not found) INN (MESALAMINE) MESALAMINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2019
NDA 211858 (pdf not found) INN (MESALAMINE) MESALAMINE (SUN PHARM) APPROVAL= AP YEAR= 2019
NDA 207271 (pdf not found) INN (MESALAMINE) MESALAMINE (MYLAN) APPROVAL= AP YEAR= 2019
NDA 208953 (pdf not found) INN (MESALAMINE) MESALAMINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2020
NDA 210509 (pdf not found) INN (MESALAMINE) MESALAMINE (AMNEAL) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 213377 (pdf not found) INN (MESALAMINE) MESALAMINE (ANNORA PHARMA) APPROVAL= AP YEAR= 2020
NDA 205654 (pdf not found) INN (MESALAMINE) MESALAMINE (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 2020
NDA 208954 (pdf not found) INN (MESALAMINE) MESALAMINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2021
NDA 214242 (pdf not found) INN (MESALAMINE) MESALAMINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2021
NDA 209970 (pdf not found) INN (MESALAMINE) MESALAMINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 214585 (pdf not found) INN (MESALAMINE) MESALAMINE (SUN PHARM) APPROVAL= AP YEAR= 2022
NDA 216967 (pdf not found) INN (MESALAMINE) MESALAMINE (ALEMBIC) APPROVAL= AP YEAR= 2022
NDA 214477 (pdf not found) INN (MESALAMINE) MESALAMINE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 216941 (pdf not found) INN (MESALAMINE) MESALAMINE (ENCUBE) APPROVAL= AP YEAR= 2023
NDA 217337 (pdf not found) INN (MESALAMINE) MESALAMINE (SINOTHERAPEUTICS INC) APPROVAL= AP YEAR= 2023
NDA 217533 (pdf not found) INN (MESALAMINE) MESALAMINE (AMTA) APPROVAL= AP YEAR= 2023
NDA 216334 (pdf not found) INN (MESALAMINE) MESALAMINE (ANNORA PHARMA) APPROVAL= AP YEAR= 2024
NDA 213191 (pdf not found) INN (MESALAMINE) MESALAMINE (TEVA PHARMS INC) APPROVAL= AP YEAR= 2024
NDA 218410 (pdf not found) INN (MESALAMINE) MESALAMINE (NOVAST LABS) APPROVAL= AP YEAR= 2024
NDA 215067 (pdf not found) INN (MESALAMINE) MESALAMINE (AMNEAL) APPROVAL= AP YEAR= 2025
NDA 215269 (pdf not found) INN (MESALAMINE) MESALAMINE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2025
NDA 219028 (pdf not found) INN (MESALAMINE) MESALAMINE (RISING) APPROVAL= AP YEAR= 2025
NDA 219864 (pdf not found) INN (MESALAMINE) MESALAMINE (ANNORA PHARMA) APPROVAL= AP YEAR= 2025
NDA 219997 (pdf not found) INN (MESALAMINE) MESALAMINE (DIFGEN PHARMS) APPROVAL= AP YEAR= 2026
NDA 220016 (pdf not found) INN (MESALAMINE) MESALAMINE (KLM LABS PVT) APPROVAL= AP YEAR= 2026