e-Drug3D

766

PENCICLOVIR

INN
PENCICLOVIR

(is an active metabolite) (has an active metabolite)

cas 39809-25-1

CLASS

ANTIINFECTIVES
ANTIVIRAL
TREATMENT OF HERPES VIRUS HSV-1 AND HSV-2

ROUTE (list)

TOPICAL

ATC code

D06BB06
J05AB13

PK parameters

Tmax 0.7 HOUR
Cmax 15.8 MICROMOLAR
VD 71.5 LITER (65 KILOGRAM)
Cl 32.7 LITER / HOUR (65 KILOGRAM)
PPB 14 PERCENT
t1/2 2.1 HOUR

Solubility

OF 1.7 MILLIGRAM / MILLILITER IN WATER

Target

TARGET THYMIDINE KINASE

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one

Formula:
C10H15N5O3

Calculated chemical properties:

MW 253.27
NB_atoms 18
XLogP -1.31
PSA 120.44
NB_HD 5
NB_HA 8
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 020629 (label) INN (PENCICLOVIR) DENAVIR (MYLAN) APPROVAL= AP YEAR= 1996 NEWMOLECULARENTITY
NDA 212710 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (TEVA PHARMS USA) APPROVAL= AP YEAR= 2022
NDA 216981 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (TORRENT) APPROVAL= AP YEAR= 2023
NDA 212368 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2024
NDA 214100 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (AMNEAL) APPROVAL= AP YEAR= 2025

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

722

FAMCICLOVIR

INN
FAMCICLOVIR

(has an active metabolite)

cas 104227-87-4

CLASS

ANTIINFECTIVES
ANTIVIRAL
DNA POLYMERASE INHIBITOR
PRODRUG OF PENCICLOVIR
TREATMENT OF HERPES VIRUS HSV-1 AND HSV-2

ROUTE (list)

ORAL

ATC code

J05AB09
S01AD07

PK parameters

F 77 PERCENT

Solubility

IS FREELY SOLUBLE (>25 PERCENT) IN WATER INITIALLY BUT RAPIDLY PRECIPITATES AS THE SPARINGLY SOLUBLE (2-3 PERCENT) MONOHYDRATE

Target

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate

Formula:
C14H19N5O4

Calculated chemical properties:

MW 321.34
NB_atoms 23
XLogP 0.54
PSA 112.592
NB_HD 2
NB_HA 9
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 020363 (label) INN (FAMCICLOVIR) FAMVIR (NOVARTIS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 077487 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (TEVA PHARMS) APPROVAL= AP YEAR= 2007
NDA 090128 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (HIKMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 078278 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (CIPLA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091114 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2011
NDA 201333 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (NATCO PHARMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091480 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (APOTEX) APPROVAL= AP YEAR= 2011
NDA 201022 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 202438 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (HETERO LABS LTD V) APPROVAL= AP YEAR= 2014