e-Drug3D

706

SPIRAPRIL

DISCONTINUED

INN
SPIRAPRIL

(has an active metabolite)

cas 83647-97-6

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

ROUTE (list)

ORAL

ATC code

C09AA11

PK parameters

Target

TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE)

Angiotensin-converting enzyme UNIPROT P12821 ACE

Download SDF file

(7S)-8-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-8-azaspiro[4.4]nonane-7-carboxylic acid

Formula:
C22H30N2O5S2

Calculated chemical properties:

MW 465.61
NB_atoms 31
XLogP 1.06
PSA 89.33
NB_HD 1
NB_HA 7
fsp3 0.59
Lipinski(0=no;1=yes) 1

FDA
NDA 020240 (label) INN (SPIRAPRIL HYDROCHLORIDE) RENORMAX (SCHERING) APPROVAL= - YEAR= 0 DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

1681

SPIRAPRILAT

INN
SPIRAPRILAT

(is an active metabolite)

cas 83602-05-5

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

ROUTE (list)

-

ATC code

C09AA11

PK parameters

Target

TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE)

Angiotensin-converting enzyme UNIPROT P12821 ACE

Download SDF file

1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-, (8S)-

Formula:
C20H26N2O5S2

Calculated chemical properties:

MW 436.55
NB_atoms 29
XLogP -0.76
PSA 101.013
NB_HD 1
NB_HA 7
fsp3 0.55
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL