e-Drug3D

692

cas 82834-16-0

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ACE INHIBITOR

ROUTE (list)

ORAL

PK parameters

F 75 PERCENT
Tmax 1 HOUR
PPB 60 PERCENT
t1/2 0.9 HOUR

MW 367.46
NB_atoms 26
XLogP 0.61
PSA 84.841
NB_HD 1
NB_HA 7
fsp3 0.84
Lipinski(0=no;1=yes) 1

FDA
NDA 020184 (label) INN (PERINDOPRIL ERBUMINE) ACEON (SYMPLMED PHARMS LLC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 078138 (pdf not found) INN (PERINDOPRIL ERBUMINE) PERINDOPRIL ERBUMINE (ANI PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 079070 (pdf not found) INN (PERINDOPRIL ERBUMINE) PERINDOPRIL ERBUMINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2009
NDA 090072 (pdf not found) INN (PERINDOPRIL ERBUMINE) PERINDOPRIL ERBUMINE (HIKMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078263 (pdf not found) INN (PERINDOPRIL ERBUMINE) PERINDOPRIL ERBUMINE (LUPIN LTD) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090463 (pdf not found) INN (PERINDOPRIL ERBUMINE) PERINDOPRIL ERBUMINE (APOTEX) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 205003 (label) INN (AMLODIPINE BESYLATE ; PERINDOPRIL ARGININE) PRESTALIA (ADHERA) APPROVAL= AP YEAR= 2015 DISCONTINUED

e-Drug3D

1685

cas 95153-31-4

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ACE INHIBITOR

ROUTE (list)

-

PK parameters

F 25 PERCENT
Tmax 5 HOUR
VD 49.4 LITER (65 KILOGRAM)
Cl 6.6 LITER / HOUR (65 KILOGRAM)
PPB 15 PERCENT
t1/2 29 HOUR

TARGET ANGIOTENSIN-CONVERTING ENZYME

PDB
2X94 (CRYSTAL STRUCTURE OF ANCE-PERINDOPRILAT COMPLEX)

Ligand code = X94 (link to the list of PDB complexes)

Download experimental 3D coordinates of X94 with added hydrogens

MW 338.40
NB_atoms 24
XLogP -1.21
PSA 93.411
NB_HD 1
NB_HA 7
fsp3 0.82
Lipinski(0=no;1=yes) 1

FDA
-