e-Drug3D

689

ALATROFLOXACIN

DISCONTINUED

INN
ALATROFLOXACIN

(has an active metabolite)

cas 146961-76-4

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
FLUOROQUINOLONE

ROUTE (list)

INJECTION

ATC code

J01MA13

PK parameters

Target

TARGET DNA GYRASE SUBUNIT A
DNA TOPOISOMERASE 4 SUBUNIT A
DNA TOPOISOMERASE 2-ALPHA

DrugCentral

Topoisomerase IV UNIPROT P0AFI2 parC

DNA gyrase UNIPROT P0AES4 gyrA

Download SDF file

L-Alaninamide, L-alanyl-N-[(1.alpha.,5.alpha.,6.alpha.)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-

Formula:
C26H25F3N6O5

Calculated chemical properties:

MW 557.51
NB_atoms 40
XLogP -0.43
PSA 147.083
NB_HD 4
NB_HA 11
fsp3 0.35
Lipinski(0=no;1=yes) 0

FDA
NDA 020760 (pdf not found) INN (ALATROFLOXACIN MESYLATE) TROVAN PRESERVATIVE FREE (PFIZER) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

1276

TROVAFLOXACIN

DISCONTINUED

INN
TROVAFLOXACIN

(is an active metabolite)

cas 147059-72-1

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
FLUOROQUINOLONES

ROUTE (list)

ORAL

ATC code

J01MA13

PK parameters

VD 84.5 LITER (65 KILOGRAM)
Cl 5.4 LITER / HOUR (65 KILOGRAM)
PPB 76 PERCENT
t1/2 9 HOUR

Target

TARGET DNA GYRASE SUBUNIT A
DNA TOPOISOMERASE 4 SUBUNIT A
DNA TOPOISOMERASE 2-ALPHA

PDB
4Z53 (QUINOLONE(TROVAFLOXACIN)-DNA CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM S. PNEUMONIAE)

Ligand code = TR6 (link to the list of PDB complexes)

Download experimental 3D coordinates of TR6 with added hydrogens

DrugCentral

Topoisomerase IV UNIPROT P0AFI2 parC

DNA gyrase UNIPROT P0AES4 gyrA

Download SDF file

7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Formula:
C20H15F3N4O3

Calculated chemical properties:

MW 415.35
NB_atoms 30
XLogP 0.56
PSA 89.254
NB_HD 2
NB_HA 7
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 020759 (pdf not found) INN (TROVAFLOXACIN MESYLATE) TROVAN (PFIZER) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 050762 (label) INN (AZITHROMYCIN DIHYDRATE ; TROVAFLOXACIN MESYLATE) TROVAN/ZITHROMAX COMPLIANCE PAK (PFIZER) APPROVAL= AP YEAR= 1998 DISCONTINUED