e-Drug3D

623

GANCICLOVIR

INN
GANCICLOVIR

(is an active metabolite) (has an active metabolite)

cas 82410-32-0

CLASS

ANTIINFECTIVES
ANTIVIRAL
CYTOMEGALOVIRUS (CMV)
HERPES SIMPLEX VIRUS (HSV)
ACYCLIC NUCLEOSIDE ANALOGUE OF 2'-DEOXYGUANOSINE

ROUTE (list)

INJECTION ORAL IMPLANTATION OPHTHALMIC INTRAVENOUS

ATC code

J05AB06
S01AD09

PK parameters

Tmax 2 HOUR
VD 45.7 LITER (65 KILOGRAM)
Cl 11.9 LITER / HOUR
PPB 1 PERCENT
t1/2 3.81 HOUR

Solubility

APPROXIMATELY 6 MILLIGRAM / MILLILITER AT 37 DEGREE CELSIUS

Target

TARGET THYMIDINE KINASE

PDB
1KI2 (THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I)

Ligand code = GA2 (link to the list of PDB complexes)

Download experimental 3D coordinates of GA2 with added hydrogens

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one

Formula:
C9H13N5O4

Calculated chemical properties:

MW 255.24
NB_atoms 18
XLogP -1.97
PSA 128.967
NB_HD 5
NB_HA 9
fsp3 0.44
Lipinski(0=no;1=yes) 1

FDA
NDA 076457 (pdf not found) INN (GANCICLOVIR) GANCICLOVIR (RANBAXY LABS LTD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019661 (label) INN (GANCICLOVIR SODIUM) CYTOVENE (CHEPLAPHARM) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 020460 (pdf not found) INN (GANCICLOVIR) CYTOVENE (ROCHE PALO) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 020569 (pdf not found) INN (GANCICLOVIR) VITRASERT (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 076222 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (HIKMA) APPROVAL= AP YEAR= 2003
NDA 022211 (label) INN (GANCICLOVIR) ZIRGAN (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009
NDA 090658 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010
NDA 202624 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (AM REGENT) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204950 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (PH HEALTH) APPROVAL= AP YEAR= 2016
NDA 209347 (label) INN (GANCICLOVIR) GANZYK-RTU (EXELA PHARMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 204560 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207645 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (PHARMASCIENCE INC) APPROVAL= AP YEAR= 2017
NDA 204204 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2018
NDA 212001 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (CUSTOPHARM INC) APPROVAL= AP YEAR= 2019 DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

861

VALGANCICLOVIR

INN
VALGANCICLOVIR

(has an active metabolite)

cas 175865-60-8

CLASS

ANTIINFECTIVE
ANTIVIRAL
CYTOMEGALOVIRUS (CMV) NUCLEOSIDE ANALOGUE DNA POLYMERASE INHIBITOR
HERPES SIMPLEX VIRUS (HSV)

ROUTE (list)

ORAL

ATC code

J05AB14

PK parameters

F 60 PERCENT

Solubility

SOLUBILITY OF 70 MILLIGRAM / MILLILITER IN WATER AT 25 DEGREE CELSIUS AT A PH 7.0

Target

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate

Formula:
C14H22N6O5

Calculated chemical properties:

MW 354.38
NB_atoms 25
XLogP -1.44
PSA 153.982
NB_HD 6
NB_HA 11
fsp3 0.57
Lipinski(0=no;1=yes) 0

FDA
NDA 021304 (label) INN (VALGANCICLOVIR HYDROCHLORIDE) VALCYTE (CHEPLAPHARM) APPROVAL= AP YEAR= 2001
NDA 078078 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (RANBAXY) APPROVAL= TA YEAR= 2008 OBSOLETE
NDA 022257 (label) INN (VALGANCICLOVIR HYDROCHLORIDE) VALCYTE (CHEPLAPHARM) APPROVAL= AP YEAR= 2009
NDA 200790 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2014
NDA 203511 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2014
NDA 204750 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 205166 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2016
NDA 205220 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2016
NDA 206876 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2017
NDA 209672 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (CIPLA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 212234 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2019
NDA 212890 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2020
NDA 213306 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (GRANULES) APPROVAL= AP YEAR= 2020
NDA 205151 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 210169 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2022
NDA 211475 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2022
NDA 215124 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2022
NDA 216317 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (APPCO) APPROVAL= AP YEAR= 2023
NDA 212876 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 218027 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (SPH ZHONGXI PHARM) APPROVAL= AP YEAR= 2025
NDA 218838 (pdf not found) INN (VALGANCICLOVIR HYDROCHLORIDE) VALGANCICLOVIR HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2026