e-Drug3D
590
cas 54350-48-0
CLASS
DERMATOLOGICALS
ANTIPSORIATIC
KERATOLYTIC AGENTS
ROUTE (list)
ORAL
ATC code
D05BB01
PK parameters
TARGET RETINOIC ACID RECEPTOR (RAR)
RETINOIC X RECEPTOR (RXR)
Retinoic acid receptor alpha UNIPROT P10276 RARA
Retinoic acid receptor RXR-gamma UNIPROT P48443 RXRG
Formula:
C23H30O3
Calculated chemical properties:
MW 354.47
NB_atoms 26
XLogP 5.65
PSA 32.883
NB_HD 0
NB_HA 3
fsp3 0.35
Lipinski(0=no;1=yes) 0
NB_atoms 26
XLogP 5.65
PSA 32.883
NB_HD 0
NB_HA 3
fsp3 0.35
Lipinski(0=no;1=yes) 0
FDA
NDA 019369 (pdf not found) INN (ETRETINATE) TEGISON (ROCHE) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 019369 (pdf not found) INN (ETRETINATE) TEGISON (ROCHE) APPROVAL= AP YEAR= 1986 DISCONTINUED
e-Drug3D
637
cas 55079-83-9
CLASS
DERMATOLOGICALS
ANTIPSORIATIC
KERATOLYTIC AGENTS
ROUTE (list)
ORAL
ATC code
D05BB02
PK parameters
F 72 PERCENT
Tmax 2.7 HOUR
PPB 99.9 PERCENT
t1/2 49 HOUR
TARGET RETINOIC ACID RECEPTOR (RAR)
RETINOIC X RECEPTOR (RXR)
Retinoic acid receptor alpha UNIPROT P10276 RARA
Retinoic acid receptor gamma UNIPROT P13631 RARG
Formula:
C21H26O3
Calculated chemical properties:
MW 325.41
NB_atoms 24
XLogP 3.83
PSA 42.909
NB_HD 0
NB_HA 3
fsp3 0.29
Lipinski(0=no;1=yes) 1
NB_atoms 24
XLogP 3.83
PSA 42.909
NB_HD 0
NB_HA 3
fsp3 0.29
Lipinski(0=no;1=yes) 1
FDA
NDA 019821 (label) INN (ACITRETIN) SORIATANE (STIEFEL LABS INC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 091455 (pdf not found) INN (ACITRETIN) ACITRETIN (BARR LABS INC) APPROVAL= AP YEAR= 2013
NDA 202897 (pdf not found) INN (ACITRETIN) ACITRETIN (TEVA PHARMS USA) APPROVAL= AP YEAR= 2013
NDA 204633 (pdf not found) INN (ACITRETIN) ACITRETIN (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2015
NDA 202148 (pdf not found) INN (ACITRETIN) ACITRETIN (MYLAN) APPROVAL= AP YEAR= 2015
NDA 202552 (pdf not found) INN (ACITRETIN) ACITRETIN (IMPAX LABS INC) APPROVAL= AP YEAR= 2015
NDA 203707 (pdf not found) INN (ACITRETIN) ACITRETIN (MYLAN) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 217774 (pdf not found) INN (ACITRETIN) ACITRETIN (ALEMBIC) APPROVAL= AP YEAR= 2024
NDA 019821 (label) INN (ACITRETIN) SORIATANE (STIEFEL LABS INC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 091455 (pdf not found) INN (ACITRETIN) ACITRETIN (BARR LABS INC) APPROVAL= AP YEAR= 2013
NDA 202897 (pdf not found) INN (ACITRETIN) ACITRETIN (TEVA PHARMS USA) APPROVAL= AP YEAR= 2013
NDA 204633 (pdf not found) INN (ACITRETIN) ACITRETIN (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2015
NDA 202148 (pdf not found) INN (ACITRETIN) ACITRETIN (MYLAN) APPROVAL= AP YEAR= 2015
NDA 202552 (pdf not found) INN (ACITRETIN) ACITRETIN (IMPAX LABS INC) APPROVAL= AP YEAR= 2015
NDA 203707 (pdf not found) INN (ACITRETIN) ACITRETIN (MYLAN) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 217774 (pdf not found) INN (ACITRETIN) ACITRETIN (ALEMBIC) APPROVAL= AP YEAR= 2024