e-Drug3D

48

cas 59-02-9

CLASS

METABOLISM
ANTIOXIDANTS
VITAMINS
PROTECTS AGAINST FREE RADICAL DAMAGE

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

TARGET ALPHA-TOCOPHEROL TRANSFER PROTEIN (ALPHA-TTP) (PMID24231105)

PDB
5MUG (SELF-ASSEMBLED ALPHA-TOCOPHEROL TRANSFER PROTEIN NANOPARTICLES PROMOTE VITAMIN E DELIVERY ACROSS AN ENDOTHELIAL BARRIER)

Ligand code = VIV (link to the list of PDB complexes)

Download experimental 3D coordinates of VIV with added hydrogens

MW 430.69
NB_atoms 31
XLogP 8.84
PSA 27.772
NB_HD 1
NB_HA 2
fsp3 0.79
Lipinski(0=no;1=yes) 0

FDA
NDA 018933 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE ; VITAMIN A ; VITAMIN E) M.V.I.-12 LYOPHILIZED (TELIGENT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 006071 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN E) BEROCCA PN (ROCHE) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 008809 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I.-12 ADULT (HOSPIRA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 018440 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.C. 9+3 (ABRAXIS PHARM) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018439 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) MVC PLUS (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018920 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PHYTONADIONE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I. PEDIATRIC (HOSPIRA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 020176 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PANTOTHENIC ACID ; PHYTONADIONE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; VITAMIN A PALMITATE ; VITAMIN E) VITAPED (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 021625 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT (HOSPIRA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021643 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT PHARMACY BULK PACKAGE (HOSPIRA) APPROVAL= AP YEAR= 2004 NEWAPPLICATION DISCONTINUED

e-Drug3D

1419

cas 58-95-7

CLASS

METABOLISM
SUPPLEMENT
ANTIOXIDANT
VITAMIN E

ROUTE (list)

INTRAVENOUS

PK parameters

MW 472.73
NB_atoms 34
XLogP 9.06
PSA 33.524
NB_HD 0
NB_HA 3
fsp3 0.77
Lipinski(0=no;1=yes) 0

FDA
NDA 021163 (label) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) INFUVITE ADULT (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2000
NDA 021265 (label) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) INFUVITE PEDIATRIC (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2001
NDA 021559 (label) INN (ALPHA-TOCOPHEROL ACETATE) INFUVITE ADULT (SANDOZ INC) APPROVAL= AP YEAR= 2003 OBSOLETE
NDA 021646 (label) INN (TOCOPHEROL ACETATE) INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE) (SANDOZ) APPROVAL= AP YEAR= 2004 OBSOLETE
NDA 210273 (pdf not found) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) MULTIPLE VITAMINS INJECTION ADULT (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210672 (pdf not found) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) MULTIPLE VITAMINS INJECTION ADULT (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210456 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC PHARMACY BULK PACKAGE (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210671 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC (APOTEX) APPROVAL= AP YEAR= 2026