e-Drug3D

451

HALAZEPAM

DISCONTINUED

INN
HALAZEPAM

(has an active metabolite)

cas 23092-17-3

CLASS

NERVOUS SYSTEM
ANXIOLYTIC
BENZODIAZEPINES
MUSCLE RELAXANTS
SEDATIVE
PRECUSOR OF DESMETHYLDIAZEPAM (PMID6123659)

ROUTE (list)

ORAL

ATC code

N05BA13

PK parameters

Cl 24 LITER / HOUR (PMID1980307)
t1/2 21.15 HOUR

Target

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR

GABA-A receptor

Download SDF file

7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one

Formula:
C17H12ClF3N2O

Calculated chemical properties:

MW 352.74
NB_atoms 24
XLogP 4.09
PSA 27.719
NB_HD 0
NB_HA 3
fsp3 0.18
Lipinski(0=no;1=yes) 1

FDA
NDA 017736 (pdf not found) INN (HALAZEPAM) PAXIPAM (SCHERING) APPROVAL= AP YEAR= 1981 NEWMOLECULARENTITY DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

1709

M DIAZEPAM

INN
DIAZEPAM

(is an active metabolite) (has an active metabolite)

cas 1088-11-5

CLASS

NERVOUS SYSTEM
ANXIOLYTIC
BENZODIAZEPINES
MUSCLE RELAXANTS
SEDATIVE

ROUTE (list)

-

ATC code

N05BA01

PK parameters

VD 29.2 LITER (65 KILOGRAM)
Cl 0.46 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 46 HOUR

Target

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR

GABA A receptor alpha-5,beta-2,gamma-3 UNIPROT P31644 GABRA5

GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1

Download SDF file

2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-

Formula:
C15H11ClN2O

Calculated chemical properties:

MW 270.71
NB_atoms 19
XLogP 3.13
PSA 39.99
NB_HD 1
NB_HA 3
fsp3 0.07
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL