e-Drug3D
415
cas 2955-38-6
CLASS
NERVOUS SYSTEM
ANXIOLYTIC
GABA MODULATORS
HYPNOTICS AND SEDATIVES
ROUTE (list)
ORAL
ATC code
N05BA11
PK parameters
TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR
GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1
Formula:
C19H17ClN2O
Calculated chemical properties:
MW 324.80
NB_atoms 23
XLogP 3.93
PSA 28.708
NB_HD 0
NB_HA 3
fsp3 0.26
Lipinski(0=no;1=yes) 1
NB_atoms 23
XLogP 3.93
PSA 28.708
NB_HD 0
NB_HA 3
fsp3 0.26
Lipinski(0=no;1=yes) 1
FDA
NDA 017415 (pdf not found) INN (PRAZEPAM) CENTRAX (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070427 (pdf not found) INN (PRAZEPAM) PRAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070428 (pdf not found) INN (PRAZEPAM) PRAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018144 (pdf not found) INN (PRAZEPAM) CENTRAX (PARKE DAVIS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 017415 (pdf not found) INN (PRAZEPAM) CENTRAX (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070427 (pdf not found) INN (PRAZEPAM) PRAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070428 (pdf not found) INN (PRAZEPAM) PRAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018144 (pdf not found) INN (PRAZEPAM) CENTRAX (PARKE DAVIS) APPROVAL= AP YEAR= 1979 DISCONTINUED
e-Drug3D
1709
cas 1088-11-5
CLASS
NERVOUS SYSTEM
ANXIOLYTIC
BENZODIAZEPINES
MUSCLE RELAXANTS
SEDATIVE
ROUTE (list)
-
ATC code
N05BA01
PK parameters
VD 29.2 LITER (65 KILOGRAM)
Cl 0.46 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 46 HOUR
TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR
GABA A receptor alpha-5,beta-2,gamma-3 UNIPROT P31644 GABRA5
GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1
Formula:
C15H11ClN2O
Calculated chemical properties:
MW 270.71
NB_atoms 19
XLogP 3.13
PSA 39.99
NB_HD 1
NB_HA 3
fsp3 0.07
Lipinski(0=no;1=yes) 1
NB_atoms 19
XLogP 3.13
PSA 39.99
NB_HD 1
NB_HA 3
fsp3 0.07
Lipinski(0=no;1=yes) 1
FDA
-
-