e-Drug3D
380
cas 6533-00-2
CLASS
GENITO
CONTRACEPTIVE
PROGESTIN
ROUTE (list)
ORAL
PK parameters
Cmax 8.9 NANOMOLAR
PPB 97 PERCENT
t1/2 36.4 HOUR
Solubility
INSOLUBLE IN WATER
TARGET PROGESTERONE RECEPTOR
Progesterone receptor UNIPROT P06401 PGR
Formula:
C21H28O2
Calculated chemical properties:
MW 312.43
NB_atoms 23
XLogP 3.88
PSA 37.637
NB_HD 1
NB_HA 2
fsp3 0.76
Lipinski(0=no;1=yes) 1
NB_atoms 23
XLogP 3.88
PSA 37.637
NB_HD 1
NB_HA 2
fsp3 0.76
Lipinski(0=no;1=yes) 1
FDA
NDA 016672 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) OVRAL (WYETH PHARMS) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 016806 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) OVRAL-28 (WYETH PHARMS) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 017031 (label) INN (NORGESTREL) OPILL (LABORATOIRE HRA) APPROVAL= AP YEAR= 1973
NDA 017612 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) LO/OVRAL (CADENCE HEALTH) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 017802 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) LO/OVRAL-28 (WYETH PHARMS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 075288 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) LOW-OGESTREL-21 (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1999
NDA 075406 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) OGESTREL 0.5/50-21 (WATSON LABS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075840 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) CRYSELLE (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 2001
NDA 091105 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) ELINEST (NOVAST LABS LTD) APPROVAL= AP YEAR= 2012
NDA 201828 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) NORGESTREL AND ETHINYL ESTRADIOL (MYLAN LABS LTD) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 202875 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) NORGESTREL AND ETHINYL ESTRADIOL (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 202980 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) TURQOZ (LUPIN) APPROVAL= AP YEAR= 2023
NDA 016672 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) OVRAL (WYETH PHARMS) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 016806 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) OVRAL-28 (WYETH PHARMS) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 017031 (label) INN (NORGESTREL) OPILL (LABORATOIRE HRA) APPROVAL= AP YEAR= 1973
NDA 017612 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) LO/OVRAL (CADENCE HEALTH) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 017802 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) LO/OVRAL-28 (WYETH PHARMS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 075288 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) LOW-OGESTREL-21 (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1999
NDA 075406 (label) INN (ETHINYL ESTRADIOL ; NORGESTREL) OGESTREL 0.5/50-21 (WATSON LABS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075840 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) CRYSELLE (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 2001
NDA 091105 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) ELINEST (NOVAST LABS LTD) APPROVAL= AP YEAR= 2012
NDA 201828 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) NORGESTREL AND ETHINYL ESTRADIOL (MYLAN LABS LTD) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 202875 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) NORGESTREL AND ETHINYL ESTRADIOL (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 202980 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTREL) TURQOZ (LUPIN) APPROVAL= AP YEAR= 2023
e-Drug3D
619
cas 35189-28-7
CLASS
GENITO
PROGESTIN
CONTRACEPTIVES
ROUTE (list)
ORAL
PK parameters
TARGET PROGESTERONE RECEPTOR
ANDROGEN RECEPTOR
Progesterone receptor UNIPROT P06401 PGR
Formula:
C23H31NO3
Calculated chemical properties:
MW 369.49
NB_atoms 27
XLogP 4.71
PSA 55.244
NB_HD 1
NB_HA 4
fsp3 0.74
Lipinski(0=no;1=yes) 1
NB_atoms 27
XLogP 4.71
PSA 55.244
NB_HD 1
NB_HA 4
fsp3 0.74
Lipinski(0=no;1=yes) 1
FDA
NDA 019653 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO CYCLEN-21 (JANSSEN PHARMS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019697 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO TRI-CYCLEN (JANSSEN PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 021040 (label) INN (ESTRADIOL ; NORGESTIMATE) PREFEST (TEVA WOMENS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021241 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO TRI-CYCLEN LO (JANSSEN PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075804 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) SPRINTEC (BARR) APPROVAL= AP YEAR= 2002
NDA 075808 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-SPRINTEC (BARR) APPROVAL= AP YEAR= 2003
NDA 076334 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) PREVIFEM (PH HEALTH) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076335 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-PREVIFEM (PH HEALTH) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021690 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO TRI-CYCLEN 21 (ORTHO MCNEIL PHARM) APPROVAL= AP YEAR= 2005 NEWAPPLICATION
NDA 076812 (pdf not found) INN (ESTRADIOL ; NORGESTIMATE) ESTRADIOL AND NORGESTIMATE (BARR) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076626 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (WATSON LABS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076627 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (WATSON LABS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076784 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI LO SPRINTEC (BARR LABS INC) APPROVAL= AP YEAR= 2009
NDA 090479 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (WATSON LABS) APPROVAL= AP YEAR= 2011
NDA 200494 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2011
NDA 200538 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 090523 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) MONO-LINYAH (NOVAST LABS LTD) APPROVAL= AP YEAR= 2012
NDA 090524 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LINYAH (NOVAST LABS LTD) APPROVAL= AP YEAR= 2012
NDA 200541 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (LUPIN PHARMS) APPROVAL= AP YEAR= 2012
NDA 090793 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-ESTARYLLA (XIROMED) APPROVAL= AP YEAR= 2013
NDA 090794 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ESTARYLLA (XIROMED) APPROVAL= AP YEAR= 2013
NDA 091232 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LO-ESTARYLLA (XIROMED) APPROVAL= AP YEAR= 2015
NDA 200383 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015
NDA 200384 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015
NDA 202132 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (XIROMED) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203865 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203870 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 201896 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (MYLAN) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 201897 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (XIROMED) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203873 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2016
NDA 204057 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (GLENMARK SPECLT) APPROVAL= AP YEAR= 2016
NDA 205588 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (LUPIN) APPROVAL= AP YEAR= 2016
NDA 205441 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-MILI (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 205449 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) MILI (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 205630 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (LUPIN) APPROVAL= AP YEAR= 2016
NDA 205762 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LO-MILI (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 090541 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LO-LINYAH (NOVAST LABS) APPROVAL= AP YEAR= 2022
NDA 019653 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO CYCLEN-21 (JANSSEN PHARMS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019697 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO TRI-CYCLEN (JANSSEN PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 021040 (label) INN (ESTRADIOL ; NORGESTIMATE) PREFEST (TEVA WOMENS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021241 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO TRI-CYCLEN LO (JANSSEN PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075804 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) SPRINTEC (BARR) APPROVAL= AP YEAR= 2002
NDA 075808 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-SPRINTEC (BARR) APPROVAL= AP YEAR= 2003
NDA 076334 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) PREVIFEM (PH HEALTH) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076335 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-PREVIFEM (PH HEALTH) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021690 (label) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ORTHO TRI-CYCLEN 21 (ORTHO MCNEIL PHARM) APPROVAL= AP YEAR= 2005 NEWAPPLICATION
NDA 076812 (pdf not found) INN (ESTRADIOL ; NORGESTIMATE) ESTRADIOL AND NORGESTIMATE (BARR) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076626 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (WATSON LABS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076627 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (WATSON LABS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076784 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI LO SPRINTEC (BARR LABS INC) APPROVAL= AP YEAR= 2009
NDA 090479 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (WATSON LABS) APPROVAL= AP YEAR= 2011
NDA 200494 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2011
NDA 200538 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 090523 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) MONO-LINYAH (NOVAST LABS LTD) APPROVAL= AP YEAR= 2012
NDA 090524 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LINYAH (NOVAST LABS LTD) APPROVAL= AP YEAR= 2012
NDA 200541 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (LUPIN PHARMS) APPROVAL= AP YEAR= 2012
NDA 090793 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-ESTARYLLA (XIROMED) APPROVAL= AP YEAR= 2013
NDA 090794 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) ESTARYLLA (XIROMED) APPROVAL= AP YEAR= 2013
NDA 091232 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LO-ESTARYLLA (XIROMED) APPROVAL= AP YEAR= 2015
NDA 200383 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015
NDA 200384 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015
NDA 202132 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (XIROMED) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203865 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203870 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 201896 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (MYLAN) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 201897 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (XIROMED) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203873 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (NAARI PTE) APPROVAL= AP YEAR= 2016
NDA 204057 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (GLENMARK SPECLT) APPROVAL= AP YEAR= 2016
NDA 205588 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (LUPIN) APPROVAL= AP YEAR= 2016
NDA 205441 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-MILI (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 205449 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) MILI (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 205630 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) NORGESTIMATE AND ETHINYL ESTRADIOL (LUPIN) APPROVAL= AP YEAR= 2016
NDA 205762 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LO-MILI (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 090541 (pdf not found) INN (ETHINYL ESTRADIOL ; NORGESTIMATE) TRI-LO-LINYAH (NOVAST LABS) APPROVAL= AP YEAR= 2022