305
DERMATOLOGICALS
GLUCOCORTICOID
ANTIPSORIATIC
ANTIINFLAMMATORY
CORTICOSTEROID
ANTIPRURITIC
VASOCONSTRICTIVE PROPERTIES
INJECTION
ATC code
A07EA04
C05AA05
D07AC01
D07XC01
H02AB01
R01AD06
R03BA04
S01BA06
S01CB04
S02BA07
S03BA03
D07CC01
S01CA05
S03CA06
D07BC01
S01BB04
PRACTICALLY INSOLUBLE IN WATER
TARGET GLUCOCORTICOID RECEPTOR
Glucocorticoid receptor UNIPROT P04150 NR3C1
Formula:
C24H31FO6
Calculated chemical properties:
NB_atoms 31
XLogP 2.47
PSA 85.632
NB_HD 2
NB_HA 6
fsp3 0.71
Lipinski(0=no;1=yes) 1
NDA 014602 (label) INN (BETAMETHASONE ACETATE ; BETAMETHASONE SODIUM PHOSPHATE) CELESTONE SOLUSPAN (ORGANON) APPROVAL= AP YEAR= 1965
NDA 090747 (pdf not found) INN (BETAMETHASONE ACETATE ; BETAMETHASONE SODIUM PHOSPHATE) BETAMETHASONE ACETATE AND BETAMETHASONE SODIUM PHOSPHATE (AM REGENT) APPROVAL= AP YEAR= 2009
NDA 077838 (pdf not found) INN (BETAMETHASONE ACETATE ; BETAMETHASONE SODIUM PHOSPHATE) BETAMETHASONE ACETATE AND BETAMETHASONE SODIUM PHOSPHATE (HIKMA) APPROVAL= AP YEAR= 2023
304
DERMATOLOGICALS
GLUCOCORTICOID
ANTIPSORIATIC
ANTIINFLAMMATORY
CORTICOSTEROID
ANTIPRURITIC
VASOCONSTRICTIVE PROPERTIES
ORAL TOPICAL
ATC code
A07EA04
C05AA05
D07AC01
D07XC01
H02AB01
R01AD06
R03BA04
S01BA06
S01CB04
S02BA07
S03BA03
D07CC01
S01CA05
S03CA06
D07BC01
S01BB04
VD 84.5 LITER (65 KILOGRAM)
Cl 10.9 LITER / HOUR (65 KILOGRAM)
PPB 64 PERCENT
t1/2 5.6 HOUR
TARGET GLUCOCORTICOID RECEPTOR
Glucocorticoid receptor UNIPROT P04150 NR3C1
Formula:
C22H29FO5
Calculated chemical properties:
NB_atoms 28
XLogP 1.90
PSA 80.652
NB_HD 3
NB_HA 5
fsp3 0.73
Lipinski(0=no;1=yes) 1
NDA 014762 (pdf not found) INN (BETAMETHASONE) CELESTONE (SCHERING) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012657 (pdf not found) INN (BETAMETHASONE) CELESTONE (SCHERING) APPROVAL= AP YEAR= 1961 DISCONTINUED
NDA 014215 (label) INN (BETAMETHASONE) CELESTONE (MERCK SHARP DOHME) APPROVAL= AP YEAR= 1964 DISCONTINUED