e-Drug3D

295

THIOGUANINE

INN
THIOGUANINE

(has an active metabolite)

cas 154-42-7

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
TREATMENT OF ACUTE NONLYMPHOCYTIC LEUKEMIAS
THIOGUANINE IS INCORPORATED INTO THE DNA AND THE RNA OF HUMAN BONE MARROW CELLS

ROUTE (list)

ORAL

NATURAL MOLECULE (link)

ATC code

L01BB03

PK parameters

F 30 PERCENT
Tmax 8 HOUR
t1/2 5.9 HOUR

Target

TARGET HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRTASE)

Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1

Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2

Download SDF file

2-amino-3,7-dihydropurine-6-thione

Formula:
C5H5N5S

Calculated chemical properties:

MW 167.21
NB_atoms 11
XLogP 0.60
PSA 73.212
NB_HD 4
NB_HA 5
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 012429 (label) INN (THIOGUANINE) THIOGUANINE (WAYLIS THERAP) APPROVAL= AP YEAR= 1966

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

1759

M THIOGUANINE

INN
THIOGUANINE

(is an active metabolite)

cas 15867-02-4

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
TREATMENT OF ACUTE NONLYMPHOCYTIC LEUKEMIAS
THIOGUANINE IS INCORPORATED INTO THE DNA AND THE RNA OF HUMAN BONE MARROW CELLS
THIOGUANYLIC ACID IS FURTHER CONVERTED TO THE DI- AND TRI-PHOSPHATES

ROUTE (list)

-

ATC code

L01BB03

PK parameters

Target

TARGET IMP DEHYDROGENASE
GLUTAMINE-5-PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE

Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1

Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2

Download SDF file

5'-Guanylic acid, 6-thio-

Formula:
C10H14N5O7PS

Calculated chemical properties:

MW 377.29
NB_atoms 24
XLogP -2.46
PSA 179.38
NB_HD 5
NB_HA 12
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL