e-Drug3D

272

cas 16051-77-7

CLASS

CARDIOVASCULAR
VASODILATOR FROM THE RELEASE OF NITRIC OXIDE

ROUTE (list)

ORAL

PK parameters

F 100 PERCENT
VD 42.2 LITER
Cl 7 LITER / HOUR
PPB 0 PERCENT
t1/2 5 HOUR

MW 191.14
NB_atoms 13
XLogP 0
PSA 95.275
NB_HD 1
NB_HA 6
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 019091 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISMO (PROMIUS PHARMA) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 020215 (label) INN (ISOSORBIDE MONONITRATE) MONOKET (OMNIVIUM PHARMS) APPROVAL= AP YEAR= 1993
NDA 020225 (pdf not found) INN (ISOSORBIDE MONONITRATE) IMDUR (SCHERING PLOUGH) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 075037 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (GENUS) APPROVAL= AP YEAR= 1998
NDA 075041 (label) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (ALKERMES GAINESVILLE) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075147 (label) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (ANI PHARMS) APPROVAL= AP YEAR= 1998
NDA 075155 (label) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1998
NDA 075306 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075166 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (SKYEPHARMA AG) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075361 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (HIKMA PHARMS) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075395 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (ZYDUS HLTHCARE) APPROVAL= AP YEAR= 2000
NDA 075448 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075522 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (DEXCEL LTD) APPROVAL= AP YEAR= 2000
NDA 076813 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 090598 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 200270 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (TORRENT PHARMS) APPROVAL= AP YEAR= 2011
NDA 200495 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (TORRENT PHARMS) APPROVAL= AP YEAR= 2011
NDA 209684 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 210822 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (DEXCEL LTD) APPROVAL= AP YEAR= 2018
NDA 210918 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (RICONPHARMA LLC) APPROVAL= AP YEAR= 2018
NDA 214115 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (SHANDONG) APPROVAL= AP YEAR= 2022
NDA 216557 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2022
NDA 218255 (pdf not found) INN (ISOSORBIDE MONONITRATE) ISOSORBIDE MONONITRATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2024 DISCONTINUED

e-Drug3D

271

cas 87-33-2

CLASS

CARDIOVASCULAR
VASODILATOR FROM THE RELEASE OF NITRIC OXIDE AND THE SUBSEQUENT ACTIVATION OF GUANYLYL CYCLASE AND ULTIMATE RELAXATION OF VASCULAR SMOOTH MUSCLE
ANTIANGINAL

ROUTE (list)

ORAL SUBLINGUAL

PK parameters

F 25 PERCENT
VD 195 LITER
Cl 180 LITER / HOUR
PPB 28 PERCENT
t1/2 1 HOUR

MW 236.14
NB_atoms 16
XLogP 0
PSA 127.034
NB_HD 0
NB_HA 8
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 016191 (pdf not found) INN (ISOSORBIDE DINITRATE) SORBITRATE (ASTRAZENECA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086405 (pdf not found) INN (ISOSORBIDE DINITRATE) SORBITRATE (ASTRAZENECA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088124 (pdf not found) INN (ISOSORBIDE DINITRATE) SORBITRATE (ASTRAZENECA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088125 (pdf not found) INN (ISOSORBIDE DINITRATE) SORBITRATE (ASTRAZENECA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012093 (label) INN (ISOSORBIDE DINITRATE) ISORDIL (BAUSCH) APPROVAL= AP YEAR= 1959 NEWMOLECULARENTITY
NDA 012940 (pdf not found) INN (ISOSORBIDE DINITRATE) ISORDIL (BIOVAIL) APPROVAL= AP YEAR= 1961 DISCONTINUED
NDA 016192 (pdf not found) INN (ISOSORBIDE DINITRATE) SORBITRATE (ASTRAZENECA) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 016776 (pdf not found) INN (ISOSORBIDE DINITRATE) SORBITRATE (ASTRAZENECA) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 084204 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 012882 (pdf not found) INN (ISOSORBIDE DINITRATE) ISORDIL (WYETH AYERST) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 086032 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (ANI PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086054 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED OBSOLETE
NDA 086055 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086066 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 OBSOLETE
NDA 086067 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 OBSOLETE
NDA 086166 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086167 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086221 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SANDOZ) APPROVAL= AP YEAR= 1982
NDA 086222 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SANDOZ) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086223 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SANDOZ) APPROVAL= AP YEAR= 1982
NDA 086925 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (PH HEALTH) APPROVAL= AP YEAR= 1982
NDA 087537 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (PH HEALTH) APPROVAL= AP YEAR= 1982
NDA 086169 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086225 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SANDOZ) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086923 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (PH HEALTH) APPROVAL= AP YEAR= 1983
NDA 087545 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 087564 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 087946 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (PH HEALTH) APPROVAL= AP YEAR= 1984
NDA 088088 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1984
NDA 086031 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 086033 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (WATSON LABS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 086034 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (WATSON LABS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089190 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUPERPHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089191 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUPERPHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089192 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUPERPHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 019790 (label) INN (ISOSORBIDE DINITRATE) DILATRATE-SR (ENDO OPERATIONS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089367 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SANDOZ) APPROVAL= AP YEAR= 1988
NDA 040009 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 086168 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020727 (label) INN (HYDRALAZINE HYDROCHLORIDE ; ISOSORBIDE DINITRATE) BIDIL (AZURITY) APPROVAL= AP YEAR= 2005
NDA 040591 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040723 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (IMPAX LABS INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 213057 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2019
NDA 211290 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (PH HEALTH) APPROVAL= AP YEAR= 2021
NDA 215586 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE AND HYDRALAZINE HYDROCHLORIDE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2022
NDA 215723 (pdf not found) INN (ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2022
NDA 215988 (pdf not found) INN (HYDRALAZINE HYDROCHLORIDE ; ISOSORBIDE DINITRATE) ISOSORBIDE DINITRATE AND HYDRALAZINE HYDROCHLORIDE (I3 PHARMS) APPROVAL= AP YEAR= 2024