e-Drug3D

22

cas 537-46-2

CLASS

NERVOUS SYSTEM
SYMPATHOMIMETIC AMINE
PSYCHOSTIMULANTS
TREATMENT OF ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY
TREATMENT OF EXOGENOUS OBESITY
LEADS TO THE FORMATION OF REACTIVE OXYGEN SPECIES IN THE BRAIN

ROUTE (list)

ORAL

PK parameters

F 67.2 PERCENT (PMID8104133)
VD 242 LITER (65 KILOGRAM)
Cl 17.1 LITER / HOUR (65 KILOGRAM)
PPB 15 PERCENT
t1/2 12.2 HOUR

TARGET DOPAMINE TRANSPORTER (DAT)
SEROTONINE TRANSPORTER

PDB
4XP6 (X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO PSYCHOSTIMULANT METHAMPHETAMINE)

Ligand code = B40 (link to the list of PDB complexes)

Download experimental 3D coordinates of B40 with added hydrogens

MW 149.23
NB_atoms 11
XLogP 1.84
PSA 12.207
NB_HD 1
NB_HA 1
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 083889 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPEX (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086359 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 005378 (label) INN (METHAMPHETAMINE HYDROCHLORIDE) DESOXYN (AJENAT PHARMS) APPROVAL= AP YEAR= 1943
NDA 084931 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (REXAR) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 040529 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (ABLE) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 091189 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2010
NDA 203846 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2015

e-Drug3D

294

cas 156-08-1

CLASS

METABOLISM
ANTIANOREXIC
APPETITE SUPPRESSION
ANORECTIC AGENT

ROUTE (list)

ORAL

PK parameters

MW 239.35
NB_atoms 18
XLogP 3.75
PSA 5.004
NB_HD 0
NB_HA 1
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 012427 (label) INN (BENZPHETAMINE HYDROCHLORIDE) DIDREX (PFIZER) APPROVAL= AP YEAR= 1960 NEWMOLECULARENTITY DISCONTINUED
NDA 040578 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (SCINOPHARM TAIWAN) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 040714 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040747 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (TEDOR PHARM) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040773 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040845 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (IMPAX LABS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 090473 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (CHARTWELL) APPROVAL= AP YEAR= 2010
NDA 090968 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (KVK TECH) APPROVAL= AP YEAR= 2010
NDA 202061 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2012
NDA 090346 (pdf not found) INN (BENZPHETAMINE HYDROCHLORIDE) BENZPHETAMINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2015