e-Drug3D

2165

TEBIPENEM

INN
TEBIPENEM

(is an active metabolite)

cas 161715-21-5

CLASS

ANTIINFECTIVES
PENEM ANTIBACTERIAL PRODRUG FOR THE TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS (CUTI)

ROUTE (list)

-

ATC code

J01DH06

PK parameters

Tmax 1.0 HOUR
VD 66.4 LITER
Cl 34.2 LITER / HOUR
PPB 42 PERCENT
t1/2 1.6 HOUR

Target

TARGET PENICILLIN-BINDING PROTEINS (PBPS)

PDB
4QB8 (CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM M.TUBERCULOSIS FORMING MICHAELIS MENTEN WITH TEBIPENEM)

Ligand code = 1TE (link to the list of PDB complexes)

Download experimental 3D coordinates of 1TE with added hydrogens

Unknown

Download SDF file

(1R,5S,6S)-6-(1(R)-Hydroxyethyl)-1-methyl-2-(1-(2-thiazolin-2-yl)azetidin-3-ylsulfanyl)-1-carba-2-penem-3-carboxylic acid

Formula:
C16H21N3O4S2

Calculated chemical properties:

MW 382.49
NB_atoms 25
XLogP -0.67
PSA 93.729
NB_HD 1
NB_HA 7
fsp3 0.69
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

2164

TEBIPENEM PIVOXIL

INN
TEBIPENEM PIVOXIL

(has an active metabolite)

cas 161715-24-8

CLASS

ANTIINFECTIVES
PENEM ANTIBACTERIAL PRODRUG FOR THE TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS (CUTI)

ROUTE (list)

ORAL

ATC code

J01DH06

PK parameters

Solubility

SPARINGLY SOLUBLE IN WATER

Target

TARGET PENICILLIN-BINDING PROTEINS (PBPS)

Unknown

Download SDF file

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester

Formula:
C22H31N3O6S2

Calculated chemical properties:

MW 497.64
NB_atoms 33
XLogP 1.67
PSA 108.361
NB_HD 1
NB_HA 9
fsp3 0.73
Lipinski(0=no;1=yes) 1

FDA
NDA 215960 (label) INN (TEBIPENEM PIVOXIL HYDROBROMIDE) UTEBZI (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2026 NEWMOLECULARENTITY

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL