e-Drug3D

2142

cas 1907685-81-7

CLASS

NERVOUS SYSTEM
TREATMENT OF MOTOR FLUCTUATIONS IN ADULTS WITH ADVANCED PARKINSON DISEASE
MAKES MORE LEVODOPA AVAILABLE TO THE BRAIN

ROUTE (list)

SUBCUTANEOUS

PK parameters

PPB 25 PERCENT

MW 303.19
NB_atoms 20
XLogP -2.89
PSA 159.097
NB_HD 4
NB_HA 9
fsp3 0.30
Lipinski(0=no;1=yes) 0

FDA
NDA 216962 (label) INN (FOSCARBIDOPA ; FOSLEVODOPA) VYALEV (ABBVIE) APPROVAL= AP YEAR= 2024

e-Drug3D

433

cas 28860-95-9

CLASS

NERVOUS SYSTEM
ENZYME INHIBITOR (DECARBOXYLASE)
ANTIDYSKINETICS
ANTIPARKINSON AGENTS

ROUTE (list)

ORAL ENTERAL

PK parameters

F 99 PERCENT
Tmax 2.95 HOUR
PPB 36 PERCENT
t1/2 1.8 HOUR

TARGET AROMATIC-L-AMINO-ACID DECARBOXYLASE (AADC)

PDB
1JS3 (CRYSTAL STRUCTURE OF DOPA DECARBOXYLASE IN COMPLEX WITH THE INHIBITOR CARBIDOPA)

Ligand code = 142 (link to the list of PDB complexes)

Download experimental 3D coordinates of 142 with added hydrogens

MW 225.22
NB_atoms 16
XLogP -1.39
PSA 113.497
NB_HD 5
NB_HA 6
fsp3 0.30
Lipinski(0=no;1=yes) 1

FDA
NDA 073381 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073382 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073383 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017555 (label) INN (CARBIDOPA ; LEVODOPA) SINEMET (ORGANON) APPROVAL= AP YEAR= 1975
NDA 017830 (label) INN (CARBIDOPA) LODOSYN (ATON) APPROVAL= AP YEAR= 1977
NDA 019856 (label) INN (CARBIDOPA ; LEVODOPA) SINEMET CR (ORGANON LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073589 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073607 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073618 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 074260 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1993
NDA 074080 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 073586 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073587 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ANI PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073620 (pdf not found) INN (CARBIDOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED OBSOLETE
NDA 075091 (label) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (MYLAN) APPROVAL= AP YEAR= 1999
NDA 021485 (label) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) STALEVO 50 (ORION PHARMA) APPROVAL= AP YEAR= 2003
NDA 076212 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076521 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2004
NDA 076663 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (KV PHARM) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076699 (pdf not found) INN (CARBIDOPA ; LEVODOPA) PARCOPA (UCB INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076643 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBILEV (RANBAXY) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077828 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077120 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078893 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RISING) APPROVAL= AP YEAR= 2008
NDA 078536 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2008
NDA 078690 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM) APPROVAL= AP YEAR= 2009
NDA 090324 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009
NDA 090631 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 079085 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (SUN PHARM) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090786 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090833 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202323 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013
NDA 203261 (pdf not found) INN (CARBIDOPA) CARBIDOPA (ANI PHARMS) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203312 (label) INN (CARBIDOPA ; LEVODOPA) RYTARY (IMPAX) APPROVAL= AP YEAR= 2015
NDA 203952 (label) INN (CARBIDOPA ; LEVODOPA) DUOPA (ABBVIE) APPROVAL= AP YEAR= 2015
NDA 204291 (pdf not found) INN (CARBIDOPA) CARBIDOPA (ALVOGEN) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 205304 (pdf not found) INN (CARBIDOPA) CARBIDOPA (EDENBRIDGE PHARMS) APPROVAL= AP YEAR= 2016
NDA 204763 (pdf not found) INN (CARBIDOPA) CARBIDOPA (NOVEL LABS INC) APPROVAL= AP YEAR= 2017
NDA 209910 (pdf not found) INN (CARBIDOPA) CARBIDOPA (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 210341 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 211055 (pdf not found) INN (CARBIDOPA) CARBIDOPA (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2019
NDA 203424 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214092 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2021
NDA 214091 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2021
NDA 214869 (label) INN (CARBIDOPA ; LEVODOPA) DHIVY (AVION PHARMS) APPROVAL= AP YEAR= 2021
NDA 213212 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (RISING) APPROVAL= AP YEAR= 2022
NDA 216505 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON RESEARCH) APPROVAL= AP YEAR= 2022
NDA 216537 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 208895 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEVODOPA (SANDOZ INC) APPROVAL= TA YEAR= 2023
NDA 215999 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217961 (pdf not found) INN (CARBIDOPA) CARBIDOPA (REGCON HOLDINGS) APPROVAL= AP YEAR= 2023
NDA 217482 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON RESEARCH) APPROVAL= AP YEAR= 2024
NDA 217186 (label) INN (CARBIDOPA ; LEVODOPA) CREXONT (IMPAX) APPROVAL= AP YEAR= 2024
NDA 210911 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEODOPA (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2025
NDA 214495 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 218939 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2025
NDA 219231 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2025
NDA 219989 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SANDOZ INC) APPROVAL= TA YEAR= 2025
NDA 220119 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (BIOCON PHARMA LIMITED) APPROVAL= TA YEAR= 2025
NDA 218535 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (ALEMBIC) APPROVAL= AP YEAR= 2026