e-Drug3D

2127

ACECLIDINE

INN
ACECLIDINE

(has an active metabolite)

cas 59653-40-6

CLASS

SENSORY
CHOLINERGIC MUSCARINIC RECEPTOR AGONIST
TREATMENT OF PRESBYOPIA

ROUTE (list)

OPHTHALMIC

ATC code

S01EB08
S01EB58

PK parameters

Target

TARGET CHOLINERGIC MUSCARINIC RECEPTOR

Muscarinic acetylcholine receptor M1 UNIPROT P11229 ACM1_HUMAN

Muscarinic acetylcholine receptor M2 UNIPROT P08172 ACM2_HUMAN

Download SDF file

1-Azabicyclo[2.2.2]octan-3-ol, 3-acetate, (3R)- (ACI)

Formula:
C9H15NO2

Calculated chemical properties:

MW 169.22
NB_atoms 12
XLogP 0.64
PSA 30.845
NB_HD 0
NB_HA 3
fsp3 0.89
Lipinski(0=no;1=yes) 1

FDA
NDA 218585 (label) INN (ACECLIDINE HYDROCHLORIDE) VIZZ (LENZ THERAP) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

2129

M ACECLIDINE

INN
ACECLIDINE

(is an active metabolite)

cas 34583-34-1

CLASS

SENSORY
CHOLINERGIC MUSCARINIC RECEPTOR AGONIST
TREATMENT OF PRESBYOPIA

ROUTE (list)

-

ATC code

S01EB08
S01EB58

PK parameters

Target

TARGET CHOLINERGIC MUSCARINIC RECEPTOR

Muscarinic acetylcholine receptor M1 UNIPROT P11229 ACM1_HUMAN

Muscarinic acetylcholine receptor M2 UNIPROT P08172 ACM2_HUMAN

Download SDF file

1-Azabicyclo[2.2.2]octan-3-ol, (3S)- (9CI, ACI)

Formula:
C7H13NO

Calculated chemical properties:

MW 127.18
NB_atoms 9
XLogP 0.07
PSA 25.654
NB_HD 1
NB_HA 2
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

2130

M ACECLIDINE

INN
ACECLIDINE

(is an active metabolite)

cas 25333-42-0

CLASS

SENSORY
CHOLINERGIC MUSCARINIC RECEPTOR AGONIST
TREATMENT OF PRESBYOPIA

ROUTE (list)

-

ATC code

S01EB08
S01EB58

PK parameters

Target

TARGET CHOLINERGIC MUSCARINIC RECEPTOR

Muscarinic acetylcholine receptor M1 UNIPROT P11229 ACM1_HUMAN

Muscarinic acetylcholine receptor M2 UNIPROT P08172 ACM2_HUMAN

Download SDF file

1-Azabicyclo[2.2.2]octan-3-ol, (3R)- (9CI, ACI)

Formula:
C7H13NO

Calculated chemical properties:

MW 127.18
NB_atoms 9
XLogP 0.07
PSA 25.818
NB_HD 1
NB_HA 2
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL