e-Drug3D

2057

TERLIPRESSIN

INN
TERLIPRESSIN

cas 14636-12-5

CLASS

HORMONE
VASOPRESSIN RECEPTOR AGONIST WITH TWICE THE SELECTIVITY FOR VASOPRESSIN V1 RECEPTORS VERSUS V2 RECEPTORS
INDICATED TO IMPROVE KIDNEY FUNCTION IN ADULTS
THE MAJOR ACTIVE METABOLITE IS LYSINE- VASOPRESSIN

ROUTE (list)

INTRAVENOUS

ATC code

H01BA04

PK parameters

Cmax 57.4 NANOMOLAR
VD 6.3 LITER
Cl 27.4 LITER / HOUR
t1/2 0.9 HOUR

Target

TARGET VASOPRESSIN V1 RECEPTOR
VASOPRESSIN V2 RECEPTOR

DrugCentral

Vasopressin V1a receptor UNIPROT P37288

Download SDF file

Vasopressin, N-(glycylglycylglycyl)-8-L-lysine- (9CI, ACI)

Formula:
C52H74N16O15S2

Calculated chemical properties:

MW 1227.41
NB_atoms 85
XLogP -6.98
PSA 456.437
NB_HD 21
NB_HA 31
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 022231 (label) INN (TERLIPRESSIN ACETATE) TERLIVAZ (MALLINCKRODT IRELAND) APPROVAL= AP YEAR= 2022 NEWMOLECULARENTITY