e-Drug3D

2036

M FEXINIDAZOLE

INN
FEXINIDAZOLE

cas 64570-18-9

CLASS

ANTIPARASITIC
ANTIPROTOZOAL
NITROIMIDAZOLE ANTIMICROBIAL
TREATMENT OF HUMAN AFRICAN TRYPANOSOMIASIS (HAT) DUE TO TRYPANOSOMA BRUCEI GAMBIENSE

ROUTE (list)

ATC code

P01CA03

PK parameters

Tmax 6 HOUR
Cmax 63 MICROMOLAR
PPB 57 PERCENT
t1/2 23 HOUR

Target

DrugCentral

Unknown

Download SDF file

1H-Imidazole, 1-methyl-2-[[4-(methylsulfonyl)phenoxy]methyl]-5-nitro- (9CI, ACI)

Formula:
C12H13N3O5S

Calculated chemical properties:

MW 311.32
NB_atoms 21
XLogP 1.31
PSA 99.455
NB_HD 0
NB_HA 7
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

e-Drug3D

2034

FEXINIDAZOLE

INN
FEXINIDAZOLE

cas 59729-37-2

CLASS

ANTIPARASITIC
ANTIPROTOZOAL
NITROIMIDAZOLE ANTIMICROBIAL
TREATMENT OF HUMAN AFRICAN TRYPANOSOMIASIS (HAT) DUE TO TRYPANOSOMA BRUCEI GAMBIENSE

ROUTE (list)

ORAL

ATC code

P01CA03

PK parameters

Tmax 4 HOUR
Cmax 2.9 MICROMOLAR
VD 3222 LITER
Cl 161 LITER / HOUR
PPB 98 PERCENT
t1/2 15 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

DrugCentral

Unknown

Download SDF file

1H-Imidazole, 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro- (9CI, ACI)

Formula:
C12H13N3O3S

Calculated chemical properties:

MW 279.32
NB_atoms 19
XLogP 2.63
PSA 65.69
NB_HD 0
NB_HA 5
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 214429 (label) INN (FEXINIDAZOLE) FEXINIDAZOLE (SANOFI) APPROVAL= AP YEAR= 2021 NEWMOLECULARENTITY