e-Drug3D

1861

M NETARSUDIL

INN
NETARSUDIL

(is an active metabolite)

cas 1254032-16-0

CLASS

SENSORY
ANTIGLAUCOMA
RHO KINASE INHIBITOR
REDUCE IOP BY INCREASING THE OUTFLOW OF AQUEOUS HUMOR
ANTIHYPERTENSIVE

ROUTE (list)

ATC code

S01EE51
S01EX05

PK parameters

Target

TARGET RHO KINASE

DrugCentral

Rho-associated protein kinase 2 UNIPROT O75116 ROCK2

Download SDF file

Benzeneacetamide, alpha-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-

Formula:
C19H19N3O2

Calculated chemical properties:

MW 321.37
NB_atoms 24
XLogP 2.41
PSA 78.851
NB_HD 4
NB_HA 5
fsp3 0.16
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

1860

NETARSUDIL

INN
NETARSUDIL

(has an active metabolite)

cas 1254032-66-0

CLASS

SENSORY
ANTIGLAUCOMA
RHO KINASE INHIBITOR
REDUCE IOP BY INCREASING THE OUTFLOW OF AQUEOUS HUMOR
ANTIHYPERTENSIVE

ROUTE (list)

OPHTHALMIC

ATC code

S01EE51
S01EX05

PK parameters

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET RHO KINASE

DrugCentral

Rho-associated protein kinase 2 UNIPROT O75116 ROCK2

Download SDF file

Benzoic acid, 2,4-dimethyl-, [4-[(1S)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl]phenyl]methyl ester

Formula:
C28H27N3O3

Calculated chemical properties:

MW 453.53
NB_atoms 34
XLogP 4.89
PSA 82.625
NB_HD 3
NB_HA 6
fsp3 0.18
Lipinski(0=no;1=yes) 1

FDA
NDA 208254 (label) INN (NETARSUDIL MESYLATE) RHOPRESSA (ALCON LABS INC) APPROVAL= AP YEAR= 2017 NEWMOLECULARENTITY
NDA 208259 (label) INN (LATANOPROST ; NETARSUDIL DIMESYLATE) ROCKLATAN (ALCON LABS INC) APPROVAL= AP YEAR= 2019
NDA 216855 (pdf not found) INN (NETARSUDIL) NETARSUDIL MESYLATE (GLAND PHARMA LTD) APPROVAL= TA YEAR= 2024