e-Drug3D

1853

cas 68538-85-2

CLASS

VARIOUS
ANTIANEMIC
ANTIDOTE TO FOLIC ACID ANTAGONISTS
ANTINEOPLASTIC ADJUNCTS
RESCUE AFTER HIGH-DOSE METHOTREXATE THERAPY IN OSTEOSARCOMA
USE IN COMBINATION CHEMOTHERAPY WITH 5-FLUOROURACIL
RAPIDLY ABSORBED AND ENTERS THE GENERAL BODY POOL OF REDUCED FOLATES
CONVERTED TO 5-METHYLTETRAHYDROFOLIC ACID (5-METHYL-THF)

ROUTE (list)

INTRAMUSCULAR INTRAVENOUS INJECTION ORAL

PK parameters

VD 16.2 LITER (65 KILOGRAM)
Cl 22.6 LITER / HOUR (65 KILOGRAM)
PPB 91 PERCENT
t1/2 1.3 HOUR

-

PDB
3UWL (CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE)

Ligand code = FOZ (link to the list of PDB complexes)

Download experimental 3D coordinates of FOZ with added hydrogens

MW 471.44
NB_atoms 34
XLogP -3.40
PSA 203.107
NB_HD 6
NB_HA 14
fsp3 0.30
Lipinski(0=no;1=yes) 0

FDA
NDA 018342 (label) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071598 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071600 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087439 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088939 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089352 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089353 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089465 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089496 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089503 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089504 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089636 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089833 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089834 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008107 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HOSPIRA) APPROVAL= AP YEAR= 1952 NEWMOLECULARENTITY DISCONTINUED
NDA 018459 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (XANODYNE PHARM) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 070480 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ELKINS SINN) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071104 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (XANODYNE PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071198 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (BARR) APPROVAL= AP YEAR= 1987
NDA 071199 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (BARR) APPROVAL= AP YEAR= 1987
NDA 071962 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (XANODYNE PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089384 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1987
NDA 089717 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1988
NDA 072733 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 072734 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 072735 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 072736 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 081277 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 1993
NDA 081278 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (TEVA PARENTERAL) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 081224 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ELKINS SINN) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 040056 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1995
NDA 040147 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (HOSPIRA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 040174 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 1997
NDA 073099 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 073101 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074544 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997
NDA 089628 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE USA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 089915 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE USA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 040258 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999
NDA 040262 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040286 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999
NDA 040332 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075327 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ANI PHARMS INC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040335 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 2000
NDA 040347 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 2000
NDA 040338 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (AM REGENT) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 020140 (label) INN (LEVOLEUCOVORIN CALCIUM) FUSILEV (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 200753 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (SAGENT PHARMS) APPROVAL= AP YEAR= 2012
NDA 200855 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (SAGENT PHARMS) APPROVAL= AP YEAR= 2012
NDA 203563 (label) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (SANDOZ) APPROVAL= AP YEAR= 2015
NDA 203576 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206263 (label) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 208723 (label) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (ACTAVIS LLC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207547 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (AMNEAL) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 203800 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017
NDA 206516 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (ACTAVIS LLC) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 209110 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2017
NDA 207548 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (AMNEAL) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207241 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 210623 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 207226 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 210917 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 210892 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (GLAND) APPROVAL= AP YEAR= 2018
NDA 211226 (label) INN (LEVOLEUCOVORIN) KHAPZORY (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2018
NDA 211002 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (MEITHEAL) APPROVAL= AP YEAR= 2019
NDA 211003 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (MEITHEAL) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211132 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (NOVAST LABS) APPROVAL= AP YEAR= 2020
NDA 213929 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (LEADING PHARMA LLC) APPROVAL= AP YEAR= 2020
NDA 213797 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (PRAXGEN) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 217314 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (HAINAN POLY PHARM) APPROVAL= AP YEAR= 2023
NDA 216590 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (KINDOS) APPROVAL= AP YEAR= 2023
NDA 217021 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HAINAN POLY) APPROVAL= AP YEAR= 2023
NDA 218200 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (GLAND) APPROVAL= AP YEAR= 2025
NDA 220406 (label) INN (LEUCOVORIN CALCIUM) VYKOURA (AVYXA HOLDINGS) APPROVAL= AP YEAR= 2026

e-Drug3D

33

cas 59-30-3

CLASS

BLOOD
VITAMIN B9
DIETARY SUPPLEMENT

ROUTE (list)

ORAL INJECTION INTRAVENOUS

PK parameters

-

PDB
4P3R (CRYOGENIC WT DHFR, TIME-AVERAGED ENSEMBLE)

Ligand code = FOL (link to the list of PDB complexes)

Download experimental 3D coordinates of FOL with added hydrogens

MW 439.40
NB_atoms 32
XLogP -2.71
PSA 197.673
NB_HD 5
NB_HA 13
fsp3 0.21
Lipinski(0=no;1=yes) 0

FDA
NDA 018933 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE ; VITAMIN A ; VITAMIN E) M.V.I.-12 LYOPHILIZED (TELIGENT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080903 (pdf not found) INN (FOLIC ACID) FOLIC ACID (VALEANT PHARM INTL) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083598 (pdf not found) INN (FOLIC ACID) FOLIC ACID (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086296 (pdf not found) INN (FOLIC ACID) FOLIC ACID (VINTAGE PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088949 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PIONEER PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 006012 (pdf not found) INN (FERROUS SULFATE ; FOLIC ACID) FOLVRON (LEDERLE) APPROVAL= AP YEAR= 1946 DISCONTINUED
NDA 005897 (pdf not found) INN (FOLIC ACID) FOLVITE (WYETH PHARMS INC) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 006071 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN E) BEROCCA PN (ROCHE) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 006135 (pdf not found) INN (FOLIC ACID) FOLIC ACID (LILLY) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 008809 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I.-12 ADULT (HOSPIRA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 080680 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WATSON LABS) APPROVAL= AP YEAR= 1971
NDA 080600 (pdf not found) INN (FOLIC ACID) FOLIC ACID (HIKMA PHARMS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080784 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PUREPAC PHARM) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 083000 (pdf not found) INN (FOLIC ACID) FOLIC ACID (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080686 (pdf not found) INN (FOLIC ACID) FOLIC ACID (IMPAX LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080691 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WHITEWORTH TOWN PLSN) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080755 (pdf not found) INN (FOLIC ACID) FOLIC ACID (EVERYLIFE) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083133 (pdf not found) INN (FOLIC ACID) FOLIC ACID (TABLICAPS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083141 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WATSON LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083526 (pdf not found) INN (FOLIC ACID) FOLIC ACID (MK LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080816 (pdf not found) INN (FOLIC ACID) FOLIC ACID (LANNETT) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084158 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PHARMERAL) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084472 (pdf not found) INN (FOLIC ACID) FOLIC ACID (SANDOZ) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084915 (pdf not found) INN (FOLIC ACID) FOLIC ACID (NEXGEN PHARMA INC) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085061 (pdf not found) INN (FOLIC ACID) FOLIC ACID (CONTRACT PHARMACAL) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085141 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WATSON LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 018440 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.C. 9+3 (ABRAXIS PHARM) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087438 (pdf not found) INN (FOLIC ACID) FOLICET (MISSION PHARMA) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018439 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) MVC PLUS (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087828 (pdf not found) INN (FOLIC ACID) FOLIC ACID (USL PHARMA) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018920 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PHYTONADIONE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I. PEDIATRIC (HOSPIRA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088199 (pdf not found) INN (FOLIC ACID) FOLIC ACID (UDL) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088730 (pdf not found) INN (FOLIC ACID) FOLIC ACID (VANGARD) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 089177 (pdf not found) INN (FOLIC ACID) FOLIC ACID (BARR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089202 (pdf not found) INN (FOLIC ACID) FOLIC ACID (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 020176 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PANTOTHENIC ACID ; PHYTONADIONE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; VITAMIN A PALMITATE ; VITAMIN E) VITAPED (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 081066 (pdf not found) INN (FOLIC ACID) FOLIC ACID (BEN VENUE) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 021163 (label) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) INFUVITE ADULT (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2000
NDA 021265 (label) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) INFUVITE PEDIATRIC (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2001
NDA 021559 (label) INN (FOLIC ACID) INFUVITE ADULT (SANDOZ INC) APPROVAL= AP YEAR= 2003 OBSOLETE
NDA 021625 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT (HOSPIRA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021643 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT PHARMACY BULK PACKAGE (HOSPIRA) APPROVAL= AP YEAR= 2004 NEWAPPLICATION DISCONTINUED
NDA 021646 (label) INN (FOLIC ACID) INFUVITE PEDIATRIC PHARMACY BULK PACKAGE (SANDOZ INC) APPROVAL= AP YEAR= 2004 OBSOLETE
NDA 040514 (pdf not found) INN (FOLIC ACID) FOLIC ACID (JUBILANT CADISTA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 040582 (pdf not found) INN (FOLIC ACID) FOLIC ACID (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 040625 (pdf not found) INN (FOLIC ACID) FOLIC ACID (AMNEAL PHARM) APPROVAL= AP YEAR= 2005
NDA 040796 (pdf not found) INN (FOLIC ACID) FOLIC ACID (LEADING) APPROVAL= AP YEAR= 2009
NDA 090035 (pdf not found) INN (FOLIC ACID) FOLIC ACID (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2009
NDA 040756 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PH HEALTH) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091145 (pdf not found) INN (FOLIC ACID) FOLIC ACID (AIPING PHARM INC) APPROVAL= AP YEAR= 2013
NDA 202437 (pdf not found) INN (FOLIC ACID) FOLIC ACID (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 204418 (pdf not found) INN (FOLIC ACID) FOLIC ACID (NUVO PHARMS INC) APPROVAL= AP YEAR= 2015
NDA 211064 (pdf not found) INN (FOLIC ACID) FOLIC ACID (RISING) APPROVAL= AP YEAR= 2019
NDA 202522 (pdf not found) INN (FOLIC ACID) FOLIC ACID (XGEN PHARMS) APPROVAL= AP YEAR= 2019
NDA 210273 (pdf not found) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) MULTIPLE VITAMINS INJECTION ADULT (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210456 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC PHARMACY BULK PACKAGE (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210671 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210672 (pdf not found) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) MULTIPLE VITAMINS INJECTION ADULT (APOTEX) APPROVAL= AP YEAR= 2026
NDA 216395 (label) INN (FOLIC ACID) QUIOFIC (SOLUBIOMIX) APPROVAL= AP YEAR= 2026