e-Drug3D

1839

M DEFLAZACORT

INN
DEFLAZACORT

(is an active metabolite)

cas 13649-57-5

CLASS

HORMONES
CORTICOSTEROID
TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY (DMD)
PRODRUG
ANTI-INFLAMMATORY
IMMUNOSUPPRESSIVE

ROUTE (list)

ATC code

H02AB13

PK parameters

PPB 40 PERCENT

Target

TARGET GLUCOCORTICOID RECEPTOR

PDB
6W9L (STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH DEACETYLATED DEFLAZACORT AND PGC1A COREGULATOR FRAGMENT)

Ligand code = TUS (link to the list of PDB complexes)

Download experimental 3D coordinates of TUS with added hydrogens

DrugCentral

Unknown

Download SDF file

5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11,21-dihydroxy-2'-methyl-, (11beta,16beta)-

Formula:
C23H29NO5

Calculated chemical properties:

MW 399.47
NB_atoms 29
XLogP 1.99
PSA 85.463
NB_HD 2
NB_HA 6
fsp3 0.70
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

1838

DEFLAZACORT

INN
DEFLAZACORT

(has an active metabolite)

cas 14484-47-0

CLASS

HORMONES
CORTICOSTEROID
TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY (DMD)
PRODRUG
ANTI-INFLAMMATORY
IMMUNOSUPPRESSIVE

ROUTE (list)

ORAL

ATC code

H02AB13

PK parameters

Tmax 1 HOUR

Target

TARGET GLUCOCORTICOID RECEPTOR

DrugCentral

Unknown

Download SDF file

5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11beta,16beta)-

Formula:
C25H31NO6

Calculated chemical properties:

MW 441.51
NB_atoms 32
XLogP 2.56
PSA 90.647
NB_HD 1
NB_HA 7
fsp3 0.68
Lipinski(0=no;1=yes) 1

FDA
NDA 208684 (label) INN (DEFLAZACORT) EMFLAZA (PTC THERAP) APPROVAL= AP YEAR= 2017 NEWMOLECULARENTITY
NDA 208685 (label) INN (DEFLAZACORT) EMFLAZA (PTC THERAP) APPROVAL= AP YEAR= 2017 NEWMOLECULARENTITY
NDA 217123 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 217813 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (TRIS PHARMA INC) APPROVAL= AP YEAR= 2024
NDA 216720 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2024
NDA 216992 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2025
NDA 217741 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (SUN PHARM) APPROVAL= AP YEAR= 2025
NDA 219254 (pdf not found) INN (DEFLAZACORT) JAYTHARI (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2025
NDA 219417 (pdf not found) INN (DEFLAZACORT) PYQUVI (AUCTA) APPROVAL= AP YEAR= 2025
NDA 217173 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (AMNEAL) APPROVAL= AP YEAR= 2025
NDA 220042 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2025
NDA 219930 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2026
NDA 220709 (pdf not found) INN (DEFLAZACORT) DEFLAZACORT (BIOCON PHARMA) APPROVAL= AP YEAR= 2026