e-Drug3D
1825
cas 53-43-0
CLASS
HORMONES
TREATMENT OF MODERATE TO SEVERE DYSPAREUNIA, A SYMPTOM OF VULVAR AND VAGINAL ATROPHY, DUE TO MENOPAUSE
STEROID
IS CONVERTED INTO ACTIVE ANDROGENS AND/OR ESTROGENS
ROUTE (list)
VAGINAL
PK parameters
Solubility
INSOLUBLE IN WATER
TARGET HYDROXYSTEROID DEHYDROGENASES
5ALPHA-REDUCTASES
AROMATASES
5ALPHA-REDUCTASES
AROMATASES
PDB
1Q22 (CRYSTAL STRUCTURE OF HUMAN CHOLESTEROL SULFOTRANSFERASE (SULT2B1B) IN THE PRESENCE OF DHEA AND PAP)
Ligand code = AND (link to the list of PDB complexes)
Download experimental 3D coordinates of AND with added hydrogens
Unknown
Formula:
C19H28O2
Calculated chemical properties:
MW 288.41
NB_atoms 21
XLogP 3.88
PSA 39.203
NB_HD 1
NB_HA 2
fsp3 0.84
Lipinski(0=no;1=yes) 1
NB_atoms 21
XLogP 3.88
PSA 39.203
NB_HD 1
NB_HA 2
fsp3 0.84
Lipinski(0=no;1=yes) 1
e-Drug3D
143
cas 58-22-0
CLASS
GENITO
ANDROGENS
TREATMENT OF HYPOGONADISM
ROUTE (list)
TRANSDERMAL BUCCAL IMPLANTATION INJECTION NASAL
PK parameters
Tmax 8 HOUR
VD 65 LITER (65 KILOGRAM)
Cl 62.4 LITER / HOUR (65 KILOGRAM)
PPB 98 PERCENT
t1/2 192 HOUR
TARGET ANDROGEN RECEPTOR
PDB
1AFS (RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE)
Ligand code = TES (link to the list of PDB complexes)
Download experimental 3D coordinates of TES with added hydrogens
Androgen receptor UNIPROT P10275 AR
Formula:
C19H28O2
Calculated chemical properties:
MW 288.41
NB_atoms 21
XLogP 3.88
PSA 37.847
NB_HD 1
NB_HA 2
fsp3 0.84
Lipinski(0=no;1=yes) 1
NB_atoms 21
XLogP 3.88
PSA 37.847
NB_HD 1
NB_HA 2
fsp3 0.84
Lipinski(0=no;1=yes) 1
FDA
NDA 080911 (pdf not found) INN (TESTOSTERONE) TESTOPEL (ENDO OPERATIONS) APPROVAL= AP YEAR= 1972
NDA 086417 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (DR REDDYS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086419 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086420 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 019762 (pdf not found) INN (TESTOSTERONE) TESTODERM (ALZA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020489 (label) INN (TESTOSTERONE) ANDRODERM (ABBVIE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020791 (pdf not found) INN (TESTOSTERONE) TESTODERM TTS (ALZA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 021015 (label) INN (TESTOSTERONE) ANDROGEL (BESINS HLTHCARE) APPROVAL= AP YEAR= 2000
NDA 021454 (label) INN (TESTOSTERONE) TESTIM (ENDO OPERATIONS) APPROVAL= AP YEAR= 2002
NDA 021543 (label) INN (TESTOSTERONE) STRIANT (AUXILIUM PHARMS LLC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076737 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2006
NDA 076744 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2007
NDA 022504 (label) INN (TESTOSTERONE) AXIRON (ELI LILLY AND CO) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 021463 (label) INN (TESTOSTERONE) FORTESTA (ENDO OPERATIONS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022309 (label) INN (TESTOSTERONE) ANDROGEL (BESINS HLTHCARE) APPROVAL= AP YEAR= 2011
NDA 202763 (label) INN (TESTOSTERONE) TESTOSTERONE (ANI PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203098 (label) INN (TESTOSTERONE) TESTOSTERONE (PERRIGO ISRAEL) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204399 (label) INN (TESTOSTERONE) VOGELXO (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2014
NDA 205488 (label) INN (TESTOSTERONE) NATESTO (ACERUS) APPROVAL= AP YEAR= 2014
NDA 204571 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2015
NDA 204268 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2015
NDA 205328 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2017
NDA 204255 (label) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2017
NDA 205781 (label) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2017
NDA 207337 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (SANDOZ INC) APPROVAL= TA YEAR= 2017
NDA 091073 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2017
NDA 208061 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (LUPIN) APPROVAL= AP YEAR= 2017
NDA 209533 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (CIPLA) APPROVAL= AP YEAR= 2018
NDA 208560 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (LUPIN) APPROVAL= AP YEAR= 2019
NDA 204570 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2019
NDA 207373 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 208620 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2019
NDA 209390 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (TWI PHARMS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210835 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (XIROMED) APPROVAL= AP YEAR= 2020
NDA 209181 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (APOTEX) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212301 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2021
NDA 212882 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ALEMBIC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213922 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ALEMBIC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 209836 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (TWI PHARMS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 212984 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2021
NDA 080911 (pdf not found) INN (TESTOSTERONE) TESTOPEL (ENDO OPERATIONS) APPROVAL= AP YEAR= 1972
NDA 086417 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (DR REDDYS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086419 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086420 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 019762 (pdf not found) INN (TESTOSTERONE) TESTODERM (ALZA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020489 (label) INN (TESTOSTERONE) ANDRODERM (ABBVIE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020791 (pdf not found) INN (TESTOSTERONE) TESTODERM TTS (ALZA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 021015 (label) INN (TESTOSTERONE) ANDROGEL (BESINS HLTHCARE) APPROVAL= AP YEAR= 2000
NDA 021454 (label) INN (TESTOSTERONE) TESTIM (ENDO OPERATIONS) APPROVAL= AP YEAR= 2002
NDA 021543 (label) INN (TESTOSTERONE) STRIANT (AUXILIUM PHARMS LLC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076737 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2006
NDA 076744 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2007
NDA 022504 (label) INN (TESTOSTERONE) AXIRON (ELI LILLY AND CO) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 021463 (label) INN (TESTOSTERONE) FORTESTA (ENDO OPERATIONS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022309 (label) INN (TESTOSTERONE) ANDROGEL (BESINS HLTHCARE) APPROVAL= AP YEAR= 2011
NDA 202763 (label) INN (TESTOSTERONE) TESTOSTERONE (ANI PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203098 (label) INN (TESTOSTERONE) TESTOSTERONE (PERRIGO ISRAEL) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204399 (label) INN (TESTOSTERONE) VOGELXO (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2014
NDA 205488 (label) INN (TESTOSTERONE) NATESTO (ACERUS) APPROVAL= AP YEAR= 2014
NDA 204571 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2015
NDA 204268 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2015
NDA 205328 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2017
NDA 204255 (label) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2017
NDA 205781 (label) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2017
NDA 207337 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (SANDOZ INC) APPROVAL= TA YEAR= 2017
NDA 091073 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2017
NDA 208061 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (LUPIN) APPROVAL= AP YEAR= 2017
NDA 209533 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (CIPLA) APPROVAL= AP YEAR= 2018
NDA 208560 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (LUPIN) APPROVAL= AP YEAR= 2019
NDA 204570 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2019
NDA 207373 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 208620 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2019
NDA 209390 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (TWI PHARMS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210835 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (XIROMED) APPROVAL= AP YEAR= 2020
NDA 209181 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (APOTEX) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212301 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2021
NDA 212882 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ALEMBIC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213922 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ALEMBIC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 209836 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (TWI PHARMS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 212984 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2021
e-Drug3D
17
cas 50-28-2
CLASS
GENITO
ANTI-MENOPAUSAL AGENTS
ANTICHOLESTEREMIC AGENTS
ESTROGENS
ROUTE (list)
TRANSDERMAL VAGINAL ORAL TOPICAL INJECTION
PK parameters
Tmax 1 HOUR
VD 78 LITER (65 KILOGRAM)
Cl 117 LITER / HOUR (65 KILOGRAM)
PPB 98.4 PERCENT
t1/2 1.7 HOUR
TARGET ESTROGEN RECEPTOR
PDB
1FDU (HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+)
Ligand code = EST (link to the list of PDB complexes)
Download experimental 3D coordinates of EST with added hydrogens
Estrogen receptor UNIPROT P03372 ESR1
Formula:
C18H24O2
Calculated chemical properties:
MW 272.37
NB_atoms 20
XLogP 3.61
PSA 42.044
NB_HD 2
NB_HA 2
fsp3 0.67
Lipinski(0=no;1=yes) 1
NB_atoms 20
XLogP 3.61
PSA 42.044
NB_HD 2
NB_HA 2
fsp3 0.67
Lipinski(0=no;1=yes) 1
FDA
NDA 010753 (pdf not found) INN (POLYESTRADIOL PHOSPHATE) ESTRADURIN (WYETH AYERST) APPROVAL= AP YEAR= 1957 NEWMOLECULARENTITY DISCONTINUED
NDA 084499 (label) INN (ESTRADIOL) ESTRACE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084500 (label) INN (ESTRADIOL) ESTRACE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 086069 (label) INN (ESTRADIOL) ESTRACE (ABBVIE) APPROVAL= AP YEAR= 1984
NDA 019081 (label) INN (ESTRADIOL) ESTRADERM (NOVARTIS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 081295 (label) INN (ESTRADIOL) ESTRACE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020323 (label) INN (ESTRADIOL) VIVELLE (SANDOZ) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 020375 (label) INN (ESTRADIOL) CLIMARA (BAYER HLTHCARE) APPROVAL= AP YEAR= 1994
NDA 020417 (pdf not found) INN (ESTRADIOL) FEMPATCH (PARKE DAVIS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020472 (label) INN (ESTRADIOL) ESTRING (PFIZER) APPROVAL= AP YEAR= 1996
NDA 020538 (label) INN (ESTRADIOL) ESTRADIOL (SANDOZ) APPROVAL= AP YEAR= 1996
NDA 020655 (label) INN (ESTRADIOL) ALORA (ABBVIE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040114 (pdf not found) INN (ESTRADIOL) ESTRADIOL (RUBICON RESEARCH) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040197 (pdf not found) INN (ESTRADIOL) ESTRADIOL (BARR LABS INC) APPROVAL= AP YEAR= 1997
NDA 040212 (pdf not found) INN (ESTRADIOL) GYNODIOL (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 020847 (label) INN (ESTRADIOL) ESCLIM (WOMEN FIRST HLTHCARE) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020870 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) COMBIPATCH (NOVEN PHARMS INC) APPROVAL= AP YEAR= 1998
NDA 020907 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ACTIVELLA (AMNEAL) APPROVAL= AP YEAR= 1998
NDA 040138 (pdf not found) INN (ESTRADIOL) ESTRADIOL (LANNETT CO INC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 040275 (label) INN (ESTRADIOL) ESTRADIOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1998
NDA 020908 (label) INN (ESTRADIOL) VAGIFEM (NOVO NORDISK INC) APPROVAL= AP YEAR= 1999
NDA 021040 (label) INN (ESTRADIOL ; NORGESTIMATE) PREFEST (TEVA WOMENS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021048 (label) INN (ESTRADIOL) ESTRADIOL (ORTHO MCNEIL PHARM) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040312 (pdf not found) INN (ESTRADIOL) INNOFEM (NOVO NORDISK INC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040326 (label) INN (ESTRADIOL) ESTRADIOL (PHARMOBEDIENT) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021103 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ACTIVELLA (NOVO NORDISK) APPROVAL= AP YEAR= 2000 NEWAPPLICATION DISCONTINUED
NDA 021167 (label) INN (ESTRADIOL) VIVELLE (NOVARTIS) APPROVAL= AP YEAR= 2000 NEWAPPLICATION
NDA 075182 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2000
NDA 075233 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2000
NDA 021310 (pdf not found) INN (ESTRADIOL) ALORA (WATSON LABS) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 040297 (pdf not found) INN (ESTRADIOL) ESTRADIOL (USL PHARMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021258 (label) INN (ESTRADIOL ; LEVONORGESTREL) CLIMARA PRO (BAYER HLTHCARE) APPROVAL= AP YEAR= 2003
NDA 021371 (label) INN (ESTRADIOL HEMIHYDRATE) ESTRASORB (EXELTIS USA INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021166 (label) INN (ESTRADIOL) ESTROGEL (ASCEND THERAPS US) APPROVAL= AP YEAR= 2004
NDA 021674 (label) INN (ESTRADIOL) MENOSTAR (BAYER HLTHCARE) APPROVAL= AP YEAR= 2004 NEWAPPLICATION
NDA 021355 (label) INN (DROSPIRENONE ; ESTRADIOL) ANGELIQ (BAYER HLTHCARE) APPROVAL= AP YEAR= 2005
NDA 021885 (label) INN (ESTRADIOL ; LEVONORGESTREL) CLIMARA PRO (BERLEX LABS) APPROVAL= AP YEAR= 2005 NEWAPPLICATION
NDA 076812 (pdf not found) INN (ESTRADIOL ; NORGESTIMATE) ESTRADIOL AND NORGESTIMATE (BARR) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021813 (label) INN (ESTRADIOL) ELESTRIN (VIATRIS) APPROVAL= AP YEAR= 2006
NDA 022001 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ACTIVELLA (NOVO NORDISK INC) APPROVAL= AP YEAR= 2006 NEWAPPLICATION
NDA 022014 (label) INN (ESTRADIOL) EVAMIST (PADAGIS US) APPROVAL= AP YEAR= 2007
NDA 022038 (label) INN (ESTRADIOL) DIVIGEL (VERTICAL PHARMS) APPROVAL= AP YEAR= 2007
NDA 078324 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (BRECKENRIDGE PHARM) APPROVAL= AP YEAR= 2008
NDA 079193 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (BARR) APPROVAL= AP YEAR= 2010
NDA 200747 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203752 (label) INN (ESTRADIOL) MINIVELLE (NOVEN) APPROVAL= AP YEAR= 2012
NDA 201675 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2014
NDA 020167 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2014
NDA 205256 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL PHARMS) APPROVAL= AP YEAR= 2015
NDA 203339 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) AMABELZ (LUPIN) APPROVAL= AP YEAR= 2016
NDA 206388 (pdf not found) INN (ESTRADIOL) ESTRADIOL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2017
NDA 207261 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (XIROMED) APPROVAL= AP YEAR= 2017
NDA 208788 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN) APPROVAL= AP YEAR= 2017
NDA 208564 (label) INN (ESTRADIOL) IMVEXXY (MAYNE PHARMA) APPROVAL= AP YEAR= 2018
NDA 209767 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ENCUBE) APPROVAL= AP YEAR= 2018
NDA 210194 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2018
NDA 210233 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (NAARI PTE) APPROVAL= AP YEAR= 2018
NDA 210488 (pdf not found) INN (ESTRADIOL) ESTRADIOL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2018
NDA 206685 (label) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2018
NDA 210132 (label) INN (ESTRADIOL ; PROGESTERONE) BIJUVA (MAYNE PHARMA) APPROVAL= AP YEAR= 2018
NDA 210264 (pdf not found) INN (ESTRADIOL) ESTRADIOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2018
NDA 210612 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (NOVAST LABS) APPROVAL= AP YEAR= 2019
NDA 211293 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 211396 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL) APPROVAL= AP YEAR= 2020
NDA 213388 (label) INN (ELAGOLIX SODIUM ; ESTRADIOL ; NORETHINDRONE ACETATE ; ELAGOLIX SODIUM) ORIAHNN COPACKAGED (ABBVIE) APPROVAL= AP YEAR= 2020
NDA 214846 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE ; RELUGOLIX) MYFEMBREE (SUMITOMO PHARMA AM) APPROVAL= AP YEAR= 2021
NDA 212313 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PRASCO) APPROVAL= AP YEAR= 2021
NDA 214293 (pdf not found) INN (ESTRADIOL ; PROGESTERONE) ESTRADIOL AND PROGESTERONE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 206241 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022
NDA 211783 (pdf not found) INN (ESTRADIOL) ESTRADIOL (XIROMED) APPROVAL= AP YEAR= 2022
NDA 202985 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023
NDA 204379 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023
NDA 214729 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ETYQA (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 216524 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2023
NDA 217334 (pdf not found) INN (ESTRADIOL) ESTRADIOL (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2023
NDA 217610 (pdf not found) INN (ESTRADIOL) ESTRADIOL (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2023
NDA 216160 (pdf not found) INN (ESTRADIOL) ESTRADIOL (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2024
NDA 216055 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL) APPROVAL= AP YEAR= 2024
NDA 216550 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024
NDA 217863 (pdf not found) INN (ESTRADIOL) ESTRADIOL (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2024
NDA 217882 (pdf not found) INN (ESTRADIOL) ESTRADIOL (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2024
NDA 218507 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ENCUBE) APPROVAL= AP YEAR= 2025
NDA 214137 (pdf not found) INN (ESTRADIOL) ESTRADIOL (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2025
NDA 217650 (pdf not found) INN (ELAGOLIX ; ESTRADIOL ; NORETHINDRONE ACETATE) SHEUR (TEVA PHARM) APPROVAL= TA YEAR= 2025
NDA 218031 (pdf not found) INN (DROSPIRENONE ; ESTRADIOL) DROSPIRENONE AND ESTRADIOL (NOVAST LABS) APPROVAL= TA YEAR= 2025
NDA 215096 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PADAGIS US) APPROVAL= AP YEAR= 2026 DISCONTINUED
NDA 218214 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ENCUBE) APPROVAL= AP YEAR= 2026
NDA 010753 (pdf not found) INN (POLYESTRADIOL PHOSPHATE) ESTRADURIN (WYETH AYERST) APPROVAL= AP YEAR= 1957 NEWMOLECULARENTITY DISCONTINUED
NDA 084499 (label) INN (ESTRADIOL) ESTRACE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084500 (label) INN (ESTRADIOL) ESTRACE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 086069 (label) INN (ESTRADIOL) ESTRACE (ABBVIE) APPROVAL= AP YEAR= 1984
NDA 019081 (label) INN (ESTRADIOL) ESTRADERM (NOVARTIS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 081295 (label) INN (ESTRADIOL) ESTRACE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020323 (label) INN (ESTRADIOL) VIVELLE (SANDOZ) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 020375 (label) INN (ESTRADIOL) CLIMARA (BAYER HLTHCARE) APPROVAL= AP YEAR= 1994
NDA 020417 (pdf not found) INN (ESTRADIOL) FEMPATCH (PARKE DAVIS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020472 (label) INN (ESTRADIOL) ESTRING (PFIZER) APPROVAL= AP YEAR= 1996
NDA 020538 (label) INN (ESTRADIOL) ESTRADIOL (SANDOZ) APPROVAL= AP YEAR= 1996
NDA 020655 (label) INN (ESTRADIOL) ALORA (ABBVIE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040114 (pdf not found) INN (ESTRADIOL) ESTRADIOL (RUBICON RESEARCH) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040197 (pdf not found) INN (ESTRADIOL) ESTRADIOL (BARR LABS INC) APPROVAL= AP YEAR= 1997
NDA 040212 (pdf not found) INN (ESTRADIOL) GYNODIOL (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 020847 (label) INN (ESTRADIOL) ESCLIM (WOMEN FIRST HLTHCARE) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020870 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) COMBIPATCH (NOVEN PHARMS INC) APPROVAL= AP YEAR= 1998
NDA 020907 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ACTIVELLA (AMNEAL) APPROVAL= AP YEAR= 1998
NDA 040138 (pdf not found) INN (ESTRADIOL) ESTRADIOL (LANNETT CO INC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 040275 (label) INN (ESTRADIOL) ESTRADIOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1998
NDA 020908 (label) INN (ESTRADIOL) VAGIFEM (NOVO NORDISK INC) APPROVAL= AP YEAR= 1999
NDA 021040 (label) INN (ESTRADIOL ; NORGESTIMATE) PREFEST (TEVA WOMENS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021048 (label) INN (ESTRADIOL) ESTRADIOL (ORTHO MCNEIL PHARM) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040312 (pdf not found) INN (ESTRADIOL) INNOFEM (NOVO NORDISK INC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040326 (label) INN (ESTRADIOL) ESTRADIOL (PHARMOBEDIENT) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021103 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ACTIVELLA (NOVO NORDISK) APPROVAL= AP YEAR= 2000 NEWAPPLICATION DISCONTINUED
NDA 021167 (label) INN (ESTRADIOL) VIVELLE (NOVARTIS) APPROVAL= AP YEAR= 2000 NEWAPPLICATION
NDA 075182 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2000
NDA 075233 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2000
NDA 021310 (pdf not found) INN (ESTRADIOL) ALORA (WATSON LABS) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 040297 (pdf not found) INN (ESTRADIOL) ESTRADIOL (USL PHARMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021258 (label) INN (ESTRADIOL ; LEVONORGESTREL) CLIMARA PRO (BAYER HLTHCARE) APPROVAL= AP YEAR= 2003
NDA 021371 (label) INN (ESTRADIOL HEMIHYDRATE) ESTRASORB (EXELTIS USA INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021166 (label) INN (ESTRADIOL) ESTROGEL (ASCEND THERAPS US) APPROVAL= AP YEAR= 2004
NDA 021674 (label) INN (ESTRADIOL) MENOSTAR (BAYER HLTHCARE) APPROVAL= AP YEAR= 2004 NEWAPPLICATION
NDA 021355 (label) INN (DROSPIRENONE ; ESTRADIOL) ANGELIQ (BAYER HLTHCARE) APPROVAL= AP YEAR= 2005
NDA 021885 (label) INN (ESTRADIOL ; LEVONORGESTREL) CLIMARA PRO (BERLEX LABS) APPROVAL= AP YEAR= 2005 NEWAPPLICATION
NDA 076812 (pdf not found) INN (ESTRADIOL ; NORGESTIMATE) ESTRADIOL AND NORGESTIMATE (BARR) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021813 (label) INN (ESTRADIOL) ELESTRIN (VIATRIS) APPROVAL= AP YEAR= 2006
NDA 022001 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ACTIVELLA (NOVO NORDISK INC) APPROVAL= AP YEAR= 2006 NEWAPPLICATION
NDA 022014 (label) INN (ESTRADIOL) EVAMIST (PADAGIS US) APPROVAL= AP YEAR= 2007
NDA 022038 (label) INN (ESTRADIOL) DIVIGEL (VERTICAL PHARMS) APPROVAL= AP YEAR= 2007
NDA 078324 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (BRECKENRIDGE PHARM) APPROVAL= AP YEAR= 2008
NDA 079193 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (BARR) APPROVAL= AP YEAR= 2010
NDA 200747 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203752 (label) INN (ESTRADIOL) MINIVELLE (NOVEN) APPROVAL= AP YEAR= 2012
NDA 201675 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2014
NDA 020167 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2014
NDA 205256 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL PHARMS) APPROVAL= AP YEAR= 2015
NDA 203339 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) AMABELZ (LUPIN) APPROVAL= AP YEAR= 2016
NDA 206388 (pdf not found) INN (ESTRADIOL) ESTRADIOL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2017
NDA 207261 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (XIROMED) APPROVAL= AP YEAR= 2017
NDA 208788 (pdf not found) INN (ESTRADIOL) ESTRADIOL (MYLAN) APPROVAL= AP YEAR= 2017
NDA 208564 (label) INN (ESTRADIOL) IMVEXXY (MAYNE PHARMA) APPROVAL= AP YEAR= 2018
NDA 209767 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ENCUBE) APPROVAL= AP YEAR= 2018
NDA 210194 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2018
NDA 210233 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (NAARI PTE) APPROVAL= AP YEAR= 2018
NDA 210488 (pdf not found) INN (ESTRADIOL) ESTRADIOL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2018
NDA 206685 (label) INN (ESTRADIOL) ESTRADIOL (MYLAN TECHNOLOGIES) APPROVAL= AP YEAR= 2018
NDA 210132 (label) INN (ESTRADIOL ; PROGESTERONE) BIJUVA (MAYNE PHARMA) APPROVAL= AP YEAR= 2018
NDA 210264 (pdf not found) INN (ESTRADIOL) ESTRADIOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2018
NDA 210612 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ESTRADIOL AND NORETHINDRONE ACETATE (NOVAST LABS) APPROVAL= AP YEAR= 2019
NDA 211293 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 211396 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL) APPROVAL= AP YEAR= 2020
NDA 213388 (label) INN (ELAGOLIX SODIUM ; ESTRADIOL ; NORETHINDRONE ACETATE ; ELAGOLIX SODIUM) ORIAHNN COPACKAGED (ABBVIE) APPROVAL= AP YEAR= 2020
NDA 214846 (label) INN (ESTRADIOL ; NORETHINDRONE ACETATE ; RELUGOLIX) MYFEMBREE (SUMITOMO PHARMA AM) APPROVAL= AP YEAR= 2021
NDA 212313 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PRASCO) APPROVAL= AP YEAR= 2021
NDA 214293 (pdf not found) INN (ESTRADIOL ; PROGESTERONE) ESTRADIOL AND PROGESTERONE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 206241 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022
NDA 211783 (pdf not found) INN (ESTRADIOL) ESTRADIOL (XIROMED) APPROVAL= AP YEAR= 2022
NDA 202985 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023
NDA 204379 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023
NDA 214729 (pdf not found) INN (ESTRADIOL ; NORETHINDRONE ACETATE) ETYQA (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 216524 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2023
NDA 217334 (pdf not found) INN (ESTRADIOL) ESTRADIOL (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2023
NDA 217610 (pdf not found) INN (ESTRADIOL) ESTRADIOL (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2023
NDA 216160 (pdf not found) INN (ESTRADIOL) ESTRADIOL (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2024
NDA 216055 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AMNEAL) APPROVAL= AP YEAR= 2024
NDA 216550 (pdf not found) INN (ESTRADIOL) ESTRADIOL (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024
NDA 217863 (pdf not found) INN (ESTRADIOL) ESTRADIOL (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2024
NDA 217882 (pdf not found) INN (ESTRADIOL) ESTRADIOL (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2024
NDA 218507 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ENCUBE) APPROVAL= AP YEAR= 2025
NDA 214137 (pdf not found) INN (ESTRADIOL) ESTRADIOL (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2025
NDA 217650 (pdf not found) INN (ELAGOLIX ; ESTRADIOL ; NORETHINDRONE ACETATE) SHEUR (TEVA PHARM) APPROVAL= TA YEAR= 2025
NDA 218031 (pdf not found) INN (DROSPIRENONE ; ESTRADIOL) DROSPIRENONE AND ESTRADIOL (NOVAST LABS) APPROVAL= TA YEAR= 2025
NDA 215096 (pdf not found) INN (ESTRADIOL) ESTRADIOL (PADAGIS US) APPROVAL= AP YEAR= 2026 DISCONTINUED
NDA 218214 (pdf not found) INN (ESTRADIOL) ESTRADIOL (ENCUBE) APPROVAL= AP YEAR= 2026