e-Drug3D

1772

M AMODIAQUINE

INN
AMODIAQUINE

(is an active metabolite)

cas 79352-78-6

CLASS

ANTIPARASITIC
ANTIMALARIALS

ROUTE (list)

ATC code

P01BA06
P01BF03

PK parameters

Tmax 3 HOUR
VD 12400 LITER
Cl 34.1 LITER / HOUR
t1/2 240 HOUR

Target

DrugCentral

Unknown

Download SDF file

Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(ethylamino)methyl]-

Formula:
C18H18ClN3O

Calculated chemical properties:

MW 327.80
NB_atoms 23
XLogP 4.45
PSA 57.543
NB_HD 3
NB_HA 4
fsp3 0.17
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

AMODIAQUINE

DISCONTINUED

INN
AMODIAQUINE

(has an active metabolite)

cas 86-42-0

CLASS

ANTIPARASITIC
ANTIMALARIALS

ROUTE (list)

ORAL

ATC code

P01BA06
P01BF03

PK parameters

Tmax 1.46 HOUR
VD 46200 LITER
Cl 2380 LITER / HOUR
t1/2 12.4 HOUR

Target

PDB
4FGZ (CRYSTAL STRUCTURE OF PHOSPHOETHANOLAMINE METHYLTRANSFERASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH AMODIAQUINE)

Ligand code = CQA (link to the list of PDB complexes)

Download experimental 3D coordinates of CQA with added hydrogens

DrugCentral

Unknown

Download SDF file

4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol

Formula:
C20H22ClN3O

Calculated chemical properties:

MW 355.86
NB_atoms 25
XLogP 5.18
PSA 47.53
NB_HD 2
NB_HA 4
fsp3 0.25
Lipinski(0=no;1=yes) 0

FDA
NDA 006441 (pdf not found) INN (AMODIAQUINE HYDROCHLORIDE) CAMOQUIN HYDROCHLORIDE (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED