1754
CARDIOVASCULAR
HYPOLIPIDEMIC
ANTICHOLESTEREMIC AGENTS
ANTILIPIDEMIC AGENTS
REDUCE THE VERY LOW-DENSITY LIPOPROTEIN FRACTION
-
ATC code
C10AB01
Cmax 932.8 MICROMOLAR
PPB 96 PERCENT
t1/2 20 HOUR
PDB
7BPY (X-RAY STRUCTURE OF HUMAN PPARALPHA LIGAND BINDING DOMAIN-CLOFIBRIC ACID-SRC1 COACTIVATOR PEPTIDE CO-CRYSTALS OBTAINED BY DELIPIDATION AND CO-CRYSTALLIZATION)
Ligand code = E0O (link to the list of PDB complexes)
Download experimental 3D coordinates of E0O with added hydrogens
Peroxisome proliferator-activated receptor alpha UNIPROT Q07869 PPARA
Formula:
C10H11ClO3
Calculated chemical properties:
NB_atoms 14
XLogP 1.25
PSA 45.716
NB_HD 0
NB_HA 3
fsp3 0.30
Lipinski(0=no;1=yes) 1
-
362
CARDIOVASCULAR
HYPOLIPIDEMIC
ANTICHOLESTEREMIC AGENTS
ANTILIPIDEMIC AGENTS
REDUCE THE VERY LOW-DENSITY LIPOPROTEIN FRACTION
ORAL
ATC code
C10AB01
TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR
Peroxisome proliferator-activated receptor alpha UNIPROT Q07869 PPARA
Formula:
C12H15ClO3
Calculated chemical properties:
NB_atoms 16
XLogP 3.06
PSA 36.011
NB_HD 0
NB_HA 3
fsp3 0.42
Lipinski(0=no;1=yes) 1
NDA 072191 (pdf not found) INN (CLOFIBRATE) CLOFIBRATE (SANDOZ) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016099 (pdf not found) INN (CLOFIBRATE) ATROMID-S (WYETH AYERST) APPROVAL= AP YEAR= 1967 NEWMOLECULARENTITY DISCONTINUED
NDA 070531 (pdf not found) INN (CLOFIBRATE) CLOFIBRATE (USL PHARMA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071603 (pdf not found) INN (CLOFIBRATE) CLOFIBRATE (WATSON LABS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 072600 (pdf not found) INN (CLOFIBRATE) CLOFIBRATE (TEVA) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073396 (pdf not found) INN (CLOFIBRATE) CLOFIBRATE (BANNER PHARMACAPS) APPROVAL= AP YEAR= 1992 DISCONTINUED