e-Drug3D

1718

cas 5949-44-0

CLASS

GENITO
ANDROGEN INDICATED FOR TESTOSTERONE REPLACEMENT THERAPY IN ADULT MALES
CLIVAGE BY TISSUE ESTERASES
RAPIDLY HYDROLYZED IN TESTOSTERONE

ROUTE (list)

INTRAMUSCULAR ORAL

PK parameters

MW 456.68
NB_atoms 33
XLogP 7.96
PSA 41.224
NB_HD 0
NB_HA 3
fsp3 0.87
Lipinski(0=no;1=yes) 0

FDA
NDA 022219 (label) INN (TESTOSTERONE UNDECANOATE) AVEED (ENDO OPERATIONS) APPROVAL= AP YEAR= 2014
NDA 207583 (pdf not found) INN (TESTOSTERONE UNDECANOATE) TESTOSTERONE UNDECANOATE (HIKMA PHARMACEUTICALS USA INC) APPROVAL= TA YEAR= 2016
NDA 206089 (label) INN (TESTOSTERONE UNDECANOATE) JATENZO (TOLMAR) APPROVAL= AP YEAR= 2019
NDA 208088 (label) INN (TESTOSTERONE UNDECANOATE) TLANDO (VERITY) APPROVAL= AP YEAR= 2022
NDA 213953 (label) INN (TESTOSTERONE UNDECANOATE) KYZATREX (MARIUS) APPROVAL= AP YEAR= 2022

e-Drug3D

143

cas 58-22-0

CLASS

GENITO
ANDROGENS
TREATMENT OF HYPOGONADISM

ROUTE (list)

TRANSDERMAL BUCCAL IMPLANTATION INJECTION NASAL

PK parameters

Tmax 8 HOUR
VD 65 LITER (65 KILOGRAM)
Cl 62.4 LITER / HOUR (65 KILOGRAM)
PPB 98 PERCENT
t1/2 192 HOUR

TARGET ANDROGEN RECEPTOR

PDB
1AFS (RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE)

Ligand code = TES (link to the list of PDB complexes)

Download experimental 3D coordinates of TES with added hydrogens

MW 288.41
NB_atoms 21
XLogP 3.88
PSA 37.847
NB_HD 1
NB_HA 2
fsp3 0.84
Lipinski(0=no;1=yes) 1

FDA
NDA 080911 (pdf not found) INN (TESTOSTERONE) TESTOPEL (ENDO OPERATIONS) APPROVAL= AP YEAR= 1972
NDA 086417 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (DR REDDYS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086419 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086420 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 019762 (pdf not found) INN (TESTOSTERONE) TESTODERM (ALZA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020489 (label) INN (TESTOSTERONE) ANDRODERM (ABBVIE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020791 (pdf not found) INN (TESTOSTERONE) TESTODERM TTS (ALZA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 021015 (label) INN (TESTOSTERONE) ANDROGEL (BESINS HLTHCARE) APPROVAL= AP YEAR= 2000
NDA 021454 (label) INN (TESTOSTERONE) TESTIM (ENDO OPERATIONS) APPROVAL= AP YEAR= 2002
NDA 021543 (label) INN (TESTOSTERONE) STRIANT (AUXILIUM PHARMS LLC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076737 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2006
NDA 076744 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2007
NDA 022504 (label) INN (TESTOSTERONE) AXIRON (ELI LILLY AND CO) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 021463 (label) INN (TESTOSTERONE) FORTESTA (ENDO OPERATIONS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022309 (label) INN (TESTOSTERONE) ANDROGEL (BESINS HLTHCARE) APPROVAL= AP YEAR= 2011
NDA 202763 (label) INN (TESTOSTERONE) TESTOSTERONE (ANI PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203098 (label) INN (TESTOSTERONE) TESTOSTERONE (PERRIGO ISRAEL) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204399 (label) INN (TESTOSTERONE) VOGELXO (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2014
NDA 205488 (label) INN (TESTOSTERONE) NATESTO (ACERUS) APPROVAL= AP YEAR= 2014
NDA 204571 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2015
NDA 204268 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2015
NDA 205328 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2017
NDA 204255 (label) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2017
NDA 205781 (label) INN (TESTOSTERONE) TESTOSTERONE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2017
NDA 207337 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (SANDOZ INC) APPROVAL= TA YEAR= 2017
NDA 091073 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2017
NDA 208061 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (LUPIN) APPROVAL= AP YEAR= 2017
NDA 209533 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (CIPLA) APPROVAL= AP YEAR= 2018
NDA 208560 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (LUPIN) APPROVAL= AP YEAR= 2019
NDA 204570 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2019
NDA 207373 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 208620 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2019
NDA 209390 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (TWI PHARMS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210835 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (XIROMED) APPROVAL= AP YEAR= 2020
NDA 209181 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (APOTEX) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212301 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2021
NDA 212882 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ALEMBIC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213922 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ALEMBIC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 209836 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (TWI PHARMS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 212984 (pdf not found) INN (TESTOSTERONE) TESTOSTERONE (ENCUBE) APPROVAL= AP YEAR= 2021