e-Drug3D

1708

M SULINDAC

INN
SULINDAC

(is an active metabolite)

cas 49627-27-2

CLASS

MUSCULO-SKELETAL
ANTIINFLAMMATORY
NSAID
CYCLOOXYGENASE INHIBITORS (EC50 OF 0.02 MICROMOLAR)

ROUTE (list)

ATC code

M01AB02

PK parameters

Tmax 4.96 HOUR
PPB 97.9 PERCENT
t1/2 16.4 HOUR

Target

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
4XUH (PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH SULINDAC SULFIDE)

Ligand code = SFI (link to the list of PDB complexes)

Download experimental 3D coordinates of SFI with added hydrogens

DrugCentral

Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2

Download SDF file

1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-

Formula:
C20H17FO2S

Calculated chemical properties:

MW 339.40
NB_atoms 24
XLogP 4.02
PSA 35.69
NB_HD 0
NB_HA 2
fsp3 0.15
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

468

SULINDAC

INN
SULINDAC

(has an active metabolite)

cas 38194-50-2

CLASS

MUSCULO-SKELETAL
ANTIINFLAMMATORY
NSAID
CYCLOOXYGENASE INHIBITORS

ROUTE (list)

ORAL

ATC code

M01AB02

PK parameters

F 90 PERCENT
Tmax 2.5 HOUR
VD 170.2 LITER
Cl 20.2 LITER / HOUR
PPB 93.1 PERCENT
t1/2 7.28 HOUR

Solubility

VERY SOLUBLE AS THE SODIUM SALT OR IN BUFFERS OF PH 6 OR HIGHER

Target

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
2KAW (NMR STRUCTURE OF THE MDVL1 PDZ DOMAIN IN COMPLEX WITH ITS INHIBITOR)

Ligand code = SUZ (link to the list of PDB complexes)

Download experimental 3D coordinates of SUZ with added hydrogens

DrugCentral

Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2

Download SDF file

2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid

Formula:
C20H17FO3S

Calculated chemical properties:

MW 355.40
NB_atoms 25
XLogP 3.03
PSA 52.132
NB_HD 0
NB_HA 3
fsp3 0.15
Lipinski(0=no;1=yes) 1

FDA
NDA 017911 (label) INN (SULINDAC) CLINORIL (MERCK) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 071795 (pdf not found) INN (SULINDAC) SULINDAC (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 071891 (pdf not found) INN (SULINDAC) SULINDAC (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072050 (pdf not found) INN (SULINDAC) SULINDAC (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991
NDA 072051 (pdf not found) INN (SULINDAC) SULINDAC (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991
NDA 072710 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA) APPROVAL= AP YEAR= 1991 OBSOLETE
NDA 072711 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA) APPROVAL= AP YEAR= 1991
NDA 072712 (pdf not found) INN (SULINDAC) SULINDAC (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072713 (pdf not found) INN (SULINDAC) SULINDAC (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073261 (pdf not found) INN (SULINDAC) SULINDAC (RADIUS PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073262 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072972 (pdf not found) INN (SULINDAC) SULINDAC (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED OBSOLETE
NDA 072973 (pdf not found) INN (SULINDAC) SULINDAC (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073038 (pdf not found) INN (SULINDAC) SULINDAC (MYLAN) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073039 (pdf not found) INN (SULINDAC) SULINDAC (RISING) APPROVAL= AP YEAR= 1993 DISCONTINUED