1684
ANTIINFECTIVES
ANTI-HIV AGENTS
ANTIMETABOLITES
NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS
-
ATC code
J05AF03
DNA POLYMERASE-BETA
MITOCHONDRIAL DNA POLYMERASE-GAMMA
PDB
4DQP (TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT, DNA DUPLEX, AND DDCTP (PAIRED WITH DG OF TEMPLATE))
Ligand code = DCT (link to the list of PDB complexes)
Download experimental 3D coordinates of DCT with added hydrogens
Reverse transcriptase,RNaseH UNIPROT Q72547 pol
Formula:
C9H16N3O12P3
Calculated chemical properties:
NB_atoms 27
XLogP -2.68
PSA 216.345
NB_HD 2
NB_HA 15
fsp3 0.56
Lipinski(0=no;1=yes) 0
-
695
ANTIINFECTIVES
ANTI-HIV AGENTS
ANTIMETABOLITES
NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS
ORAL
ATC code
J05AF03
F 80 PERCENT
Tmax 0.8 HOUR
Cmax 119.4 NANOMOLAR
VD 34.7 LITER (65 KILOGRAM)
Cl 17.1 LITER / HOUR
t1/2 2 HOUR
76.4 MILLIGRAM / MILLILITER IN WATER
PDB
2VP9 (STRUCTURAL STUDIES OF NUCLEOSIDE ANALOG AND FEEDBACK INHIBITOR BINDING TO DROSOPHILA MELANOGASTER MULTISUBSTRATE DEOXYRIBONUCLEOSIDE KINASE)
Ligand code = DOC (link to the list of PDB complexes)
Download experimental 3D coordinates of DOC with added hydrogens
Reverse transcriptase,RNaseH UNIPROT Q72547 pol
Formula:
C9H13N3O3
Calculated chemical properties:
NB_atoms 15
XLogP -0.50
PSA 83.601
NB_HD 3
NB_HA 6
fsp3 0.56
Lipinski(0=no;1=yes) 1