1683
VARIOUS
RADIATION-PROTECTIVE AGENTS
REDUCTION OF THE CUMULATIVE RENAL TOXICITY OF CISPLATIN AND FOR THE REDUCTION OF THE TOXIC EFFECTS OF RADIATION ON NORMAL ORAL TISSUES
SCAVENGE REACTIVE OXYGEN SPECIES
-
ATC code
V03AF05
Cmax 35 MICROMOLAR
t1/2 0.13 HOUR
PDB
7NIZ (HUMAN 14-3-3 SIGMA IN COMPLEX WITH HUMAN ESTROGEN RECEPTOR ALPHA PEPTIDE AND LIGANDS FUSICOCCIN-A AND WR-1065)
Ligand code = UGH (link to the list of PDB complexes)
Download experimental 3D coordinates of UGH with added hydrogens
Unknown
Formula:
C5H14N2S
Calculated chemical properties:
NB_atoms 8
XLogP -0.15
PSA 39.888
NB_HD 3
NB_HA 2
fsp3 1.00
Lipinski(0=no;1=yes) 1
-
699
VARIOUS
RADIATION-PROTECTIVE AGENTS
PRODRUG
REDUCTION OF THE CUMULATIVE RENAL TOXICITY OF CISPLATIN AND FOR THE REDUCTION OF THE TOXIC EFFECTS OF RADIATION ON NORMAL ORAL TISSUES
INTESTINAL-TYPE ALKALINE PHOSPHATASE (IAP) IS A MAJOR ISOENZYME INVOLVED IN THE HYDROLYSIS OF AMIFOSTINE (PMID12577238)
INJECTION
ATC code
V03AF05
Cmax 200 MICROMOLAR
VD 7 LITER
Cl 120 LITER / HOUR
t1/2 0.13 HOUR
FREELY SOLUBLE IN WATER
TARGET ALKALINE PHOSPHATASE
Unknown
Formula:
C5H15N2O3PS
Calculated chemical properties:
NB_atoms 12
XLogP -1.51
PSA 95.428
NB_HD 3
NB_HA 5
fsp3 1.00
Lipinski(0=no;1=yes) 1