e-Drug3D
1664
cas 118292-41-4
CLASS
DERMATOLOGIC AGENTS
KERATOLYTIC AGENTS
PRODRUGS
TERATOGENS
RETINOIDS
ROUTE (list)
-
PK parameters
PPB 99 PERCENT
t1/2 18 HOUR
TARGET RETINOIC ACID RECEPTOR GAMMA
RETINOIC ACID RECEPTOR BETA
RETINOIC ACID RECEPTOR ALPHA
Retinoic acid receptor alpha UNIPROT P10276 RARA
Retinoic acid receptor beta UNIPROT P10826 RARB
Formula:
C19H17NO2S
Calculated chemical properties:
MW 322.40
NB_atoms 23
XLogP 2.62
PSA 45.059
NB_HD 0
NB_HA 3
fsp3 0.26
Lipinski(0=no;1=yes) 1
NB_atoms 23
XLogP 2.62
PSA 45.059
NB_HD 0
NB_HA 3
fsp3 0.26
Lipinski(0=no;1=yes) 1
FDA
-
-
e-Drug3D
763
cas 118292-40-3
CLASS
DERMATOLOGIC AGENTS
KERATOLYTIC AGENTS
PRODRUGS
TERATOGENS
RETINOIDS
TREATMENT OF PSORIASIS AND ACNE
RAPIDLY HYDROLYSED IN TAZAROTENIC ACID
ROUTE (list)
TOPICAL
PK parameters
t1/2 6 HOUR
TARGET RETINOIC ACID RECEPTOR
Retinoic acid receptor alpha UNIPROT P10276 RARA
Retinoic acid receptor beta UNIPROT P10826 RARB
Formula:
C21H21NO2S
Calculated chemical properties:
MW 351.46
NB_atoms 25
XLogP 4.43
PSA 36.007
NB_HD 0
NB_HA 3
fsp3 0.33
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 4.43
PSA 36.007
NB_HD 0
NB_HA 3
fsp3 0.33
Lipinski(0=no;1=yes) 1
FDA
NDA 020600 (label) INN (TAZAROTENE) TAZORAC (ALMIRALL) APPROVAL= AP YEAR= 1997
NDA 021184 (label) INN (TAZAROTENE) TAZORAC (ALMIRALL) APPROVAL= AP YEAR= 2000
NDA 202428 (label) INN (TAZAROTENE) FABIOR (MAYNE PHARMA) APPROVAL= AP YEAR= 2012
NDA 208258 (label) INN (TAZAROTENE) TAZAROTENE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2017
NDA 208662 (pdf not found) INN (TAZAROTENE) TAZAROTENE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2017
NDA 209354 (label) INN (HALOBETASOL PROPIONATE ; TAZAROTENE) DUOBRII (BAUSCH) APPROVAL= AP YEAR= 2019
NDA 211175 (pdf not found) INN (TAZAROTENE) TAZAROTENE (FOUGERA PHARMS INC) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211882 (label) INN (TAZAROTENE) ARAZLO (BAUSCH) APPROVAL= AP YEAR= 2019
NDA 214136 (pdf not found) INN (TAZAROTENE) TAZAROTENE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2022
NDA 215433 (pdf not found) INN (TAZAROTENE) TAZAROTENE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2022
NDA 213079 (pdf not found) INN (TAZAROTENE) TAZAROTENE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2023
NDA 213644 (pdf not found) INN (TAZAROTENE) TAZAROTENE (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2023
NDA 217075 (pdf not found) INN (TAZAROTENE) TAZAROTENE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2024
NDA 217190 (pdf not found) INN (HALOBETASOL PROPIONATE ; TAZAROTENE) HALOBETASOL PROPIONATE AND TAZAROTENE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2025
NDA 215393 (pdf not found) INN (TAZAROTENE) TAZAROTENE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 214560 (pdf not found) INN (TAZAROTENE) TAZAROTENE (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2025
NDA 020600 (label) INN (TAZAROTENE) TAZORAC (ALMIRALL) APPROVAL= AP YEAR= 1997
NDA 021184 (label) INN (TAZAROTENE) TAZORAC (ALMIRALL) APPROVAL= AP YEAR= 2000
NDA 202428 (label) INN (TAZAROTENE) FABIOR (MAYNE PHARMA) APPROVAL= AP YEAR= 2012
NDA 208258 (label) INN (TAZAROTENE) TAZAROTENE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2017
NDA 208662 (pdf not found) INN (TAZAROTENE) TAZAROTENE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2017
NDA 209354 (label) INN (HALOBETASOL PROPIONATE ; TAZAROTENE) DUOBRII (BAUSCH) APPROVAL= AP YEAR= 2019
NDA 211175 (pdf not found) INN (TAZAROTENE) TAZAROTENE (FOUGERA PHARMS INC) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211882 (label) INN (TAZAROTENE) ARAZLO (BAUSCH) APPROVAL= AP YEAR= 2019
NDA 214136 (pdf not found) INN (TAZAROTENE) TAZAROTENE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2022
NDA 215433 (pdf not found) INN (TAZAROTENE) TAZAROTENE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2022
NDA 213079 (pdf not found) INN (TAZAROTENE) TAZAROTENE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2023
NDA 213644 (pdf not found) INN (TAZAROTENE) TAZAROTENE (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2023
NDA 217075 (pdf not found) INN (TAZAROTENE) TAZAROTENE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2024
NDA 217190 (pdf not found) INN (HALOBETASOL PROPIONATE ; TAZAROTENE) HALOBETASOL PROPIONATE AND TAZAROTENE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2025
NDA 215393 (pdf not found) INN (TAZAROTENE) TAZAROTENE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 214560 (pdf not found) INN (TAZAROTENE) TAZAROTENE (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2025