e-Drug3D
1648
cas 54276-17-4
CLASS
SENSORY
ANTIHYPERTENSIVE
ANTIGLAUCOMA
OPHTHALMOLOGICALS
PROSTAGLANDIN ANALOGUES
FP PROSTANOID RECEPTOR AGONIST
ROUTE (list)
-
ATC code
S01EE04
PK parameters
Tmax 0.5 HOUR
Cmax 0.04 NANOMOLAR
t1/2 0.75 HOUR
TARGET FP PROSTANOID RECEPTOR
Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR
Formula:
C23H29F3O6
Calculated chemical properties:
MW 457.45
NB_atoms 32
XLogP 2.23
PSA 106.529
NB_HD 3
NB_HA 6
fsp3 0.52
Lipinski(0=no;1=yes) 1
NB_atoms 32
XLogP 2.23
PSA 106.529
NB_HD 3
NB_HA 6
fsp3 0.52
Lipinski(0=no;1=yes) 1
FDA
-
-
e-Drug3D
872
cas 157283-68-6
CLASS
SENSORY
ANTIHYPERTENSIVE
ANTIGLAUCOMA
OPHTHALMOLOGICALS
PROSTAGLANDIN ANALOGUES
FP PROSTANOID RECEPTOR AGONIST
HYDROLYZED TO THE ACTIVE FREE ACID
ROUTE (list)
OPHTHALMIC INTRACAMERAL
ATC code
S01EE04
PK parameters
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET FP PROSTANOID RECEPTOR
Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR
Formula:
C26H35F3O6
Calculated chemical properties:
MW 500.54
NB_atoms 35
XLogP 4.43
PSA 96.337
NB_HD 3
NB_HA 6
fsp3 0.58
Lipinski(0=no;1=yes) 0
NB_atoms 35
XLogP 4.43
PSA 96.337
NB_HD 3
NB_HA 6
fsp3 0.58
Lipinski(0=no;1=yes) 0
FDA
NDA 021257 (label) INN (TRAVOPROST) TRAVATAN (ALCON PHARMS LTD) APPROVAL= AP YEAR= 2001 NEWMOLECULARENTITY DISCONTINUED
NDA 021994 (label) INN (TRAVOPROST) TRAVATAN Z (SANDOZ) APPROVAL= AP YEAR= 2006
NDA 091341 (pdf not found) INN (TRAVOPROST) TRAVOPROST (PAR PHARM) APPROVAL= TA YEAR= 2011
NDA 091340 (pdf not found) INN (TRAVOPROST) TRAVOPROST (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 204822 (label) INN (TRAVOPROST) IZBA (NOVARTIS) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203431 (pdf not found) INN (TRAVOPROST) TRAVOPROST (APOTEX) APPROVAL= AP YEAR= 2015
NDA 205050 (pdf not found) INN (TRAVOPROST) TRAVOPROST (MYLAN) APPROVAL= AP YEAR= 2017
NDA 210458 (pdf not found) INN (TRAVOPROST) TRAVOPROST (ALEMBIC) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 203767 (pdf not found) INN (TRAVOPROST) TRAVOPROST (MICRO LABS) APPROVAL= AP YEAR= 2021
NDA 218010 (label) INN (TRAVOPROST) IDOSE TR (GLAUKOS) APPROVAL= AP YEAR= 2023
NDA 207040 (pdf not found) INN (TRAVOPROST) TRAVOPROST (LUPIN) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217228 (pdf not found) INN (TRAVOPROST) TRAVOPROST (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 218159 (pdf not found) INN (TRAVOPROST) TRAVOPROST (GLAND) APPROVAL= AP YEAR= 2024
NDA 214687 (pdf not found) INN (TRAVOPROST) TRAVOPROST (ALEMBIC) APPROVAL= AP YEAR= 2025
NDA 021257 (label) INN (TRAVOPROST) TRAVATAN (ALCON PHARMS LTD) APPROVAL= AP YEAR= 2001 NEWMOLECULARENTITY DISCONTINUED
NDA 021994 (label) INN (TRAVOPROST) TRAVATAN Z (SANDOZ) APPROVAL= AP YEAR= 2006
NDA 091341 (pdf not found) INN (TRAVOPROST) TRAVOPROST (PAR PHARM) APPROVAL= TA YEAR= 2011
NDA 091340 (pdf not found) INN (TRAVOPROST) TRAVOPROST (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 204822 (label) INN (TRAVOPROST) IZBA (NOVARTIS) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203431 (pdf not found) INN (TRAVOPROST) TRAVOPROST (APOTEX) APPROVAL= AP YEAR= 2015
NDA 205050 (pdf not found) INN (TRAVOPROST) TRAVOPROST (MYLAN) APPROVAL= AP YEAR= 2017
NDA 210458 (pdf not found) INN (TRAVOPROST) TRAVOPROST (ALEMBIC) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 203767 (pdf not found) INN (TRAVOPROST) TRAVOPROST (MICRO LABS) APPROVAL= AP YEAR= 2021
NDA 218010 (label) INN (TRAVOPROST) IDOSE TR (GLAUKOS) APPROVAL= AP YEAR= 2023
NDA 207040 (pdf not found) INN (TRAVOPROST) TRAVOPROST (LUPIN) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217228 (pdf not found) INN (TRAVOPROST) TRAVOPROST (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 218159 (pdf not found) INN (TRAVOPROST) TRAVOPROST (GLAND) APPROVAL= AP YEAR= 2024
NDA 214687 (pdf not found) INN (TRAVOPROST) TRAVOPROST (ALEMBIC) APPROVAL= AP YEAR= 2025