e-Drug3D

1567

cas 5747-48-8

CLASS

NERVOUS SYSTEM
ANTIPSYCHOTIC
SCHIZOPHRENIA
DIBENZOTHIAZEPINE FAMILY
DOPAMINE D2 RECEPTOR ANTAGONIST (IC50=329 NANOMOLAR)
SEROTONIN (5HT2) ANTAGONIST (IC50=148 NANOMOLAR)
SEROTONIN 5HT1A ANTAGONIST (IC50=717 NANOMOLAR)
DOPAMINE D1 ANTAGONIST (IC50=1268 NANOMOLAR)
HISTAMINE H1 ANTAGONIST (IC50=30 NANOMOLAR)
ADRENERGIC ALPHA 1 RECEPTOR ANTAGONIST (IC50= 94 NANOMOLAR)
ADRENARGIC ALPHA 2 RECEPTOR ANTAGONIST (IC50=271 NANOMOLAR)
NO APPRECIABLE AFFINITY AT CHOLINERGIC MUSCARINIC AND BENZODIAZEPINE RECEPTORS (IC50 SUPERIOR TO 5000 NANOMOLAR)

ROUTE (list)

-

PK parameters

MW 295.41
NB_atoms 21
XLogP 3.13
PSA 25.567
NB_HD 1
NB_HA 3
fsp3 0.24
Lipinski(0=no;1=yes) 1

FDA
-

e-Drug3D

1269

cas 111974-69-7

CLASS

NERVOUS SYSTEM
ANTIPSYCHOTIC
SCHIZOPHRENIA
DIBENZOTHIAZEPINE FAMILY
DOPAMINE D2 RECEPTOR ANTAGONIST (IC50=329 NANOMOLAR)
SEROTONIN (5HT2) ANTAGONIST (IC50=148 NANOMOLAR)
SEROTONIN 5HT1A ANTAGONIST (IC50=717 NANOMOLAR)
DOPAMINE D1 ANTAGONIST (IC50=1268 NANOMOLAR)
HISTAMINE H1 ANTAGONIST (IC50=30 NANOMOLAR)
ADRENERGIC ALPHA 1 RECEPTOR ANTAGONIST (IC50= 94 NANOMOLAR)
ADRENARGIC ALPHA 2 RECEPTOR ANTAGONIST (IC50=271 NANOMOLAR)
NO APPRECIABLE AFFINITY AT CHOLINERGIC MUSCARINIC AND BENZODIAZEPINE RECEPTORS (IC50 SUPERIOR TO 5000 NANOMOLAR)

ROUTE (list)

ORAL

PK parameters

F 100 PERCENT
VD 650 LITER (65 KILOGRAM)
Cl 75 LITER / HOUR (EQN)
PPB 83 PERCENT
t1/2 6 HOUR

MW 383.51
NB_atoms 27
XLogP 2.86
PSA 47.956
NB_HD 1
NB_HA 5
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 020639 (label) INN (QUETIAPINE FUMARATE) SEROQUEL (CHEPLAPHARM) APPROVAL= AP YEAR= 1997
NDA 022047 (label) INN (QUETIAPINE FUMARATE) SEROQUEL XR (CHEPLAPHARM) APPROVAL= AP YEAR= 2007
NDA 022172 (label) INN (QUETIAPINE FUMARATE) SEROQUEL XR (CHEPLAPHARM ARZNEIMITTEL GMBH) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 077380 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (RISING) APPROVAL= AP YEAR= 2012
NDA 077745 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (TEVA PHARMS) APPROVAL= AP YEAR= 2012
NDA 090120 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (HIKMA) APPROVAL= AP YEAR= 2012
NDA 090749 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (HIKMA) APPROVAL= AP YEAR= 2012
NDA 078679 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (CHARTWELL RX) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090323 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090960 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2012
NDA 091388 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 200363 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (TORRENT PHARMS LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201109 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (LUPIN LTD) APPROVAL= AP YEAR= 2012
NDA 201190 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (SUN PHARM) APPROVAL= AP YEAR= 2012
NDA 202152 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2012
NDA 201504 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2013
NDA 201762 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (ACTAVIS GRP PTC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203150 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203390 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (ALEMBIC) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 090681 (label) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2016
NDA 202674 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (UNICHEM) APPROVAL= AP YEAR= 2016
NDA 203359 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 090482 (label) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (PH HEALTH) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 202939 (label) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (PLATINUM) APPROVAL= AP YEAR= 2017
NDA 204203 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (LUPIN) APPROVAL= AP YEAR= 2017
NDA 206252 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 206260 (label) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (PHARMADAX) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 090757 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (PH HEALTH) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 204253 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 207655 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2017
NDA 208947 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (NOVAST LABS) APPROVAL= AP YEAR= 2017
NDA 209635 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2017
NDA 209497 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (ALIGNSCIENCE PHARMA) APPROVAL= AP YEAR= 2018
NDA 211405 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 202228 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (RISING) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 204316 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2022
NDA 208781 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 206954 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 215478 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (UNICHEM) APPROVAL= AP YEAR= 2022
NDA 205983 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (IPCA LABS LTD) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 211144 (pdf not found) INN (QUETIAPINE FUMARATE) QUETIAPINE FUMARATE (RISING) APPROVAL= AP YEAR= 2024