e-Drug3D

1541

cas 147083-93-0

CLASS

RESPIRATORY
ALLERGIC CONJUNCTIVITIS
H1 HISTAMINE RECEPTOR ANTAGONIST

ROUTE (list)

-

PK parameters

Tmax 1 HOUR
Cmax 9.28 NANOMOLAR
PPB 62.7 PERCENT
t1/2 2 HOUR

MW 322.38
NB_atoms 24
XLogP 1.33
PSA 51.42
NB_HD 0
NB_HA 5
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
-

e-Drug3D

1496

cas 147084-10-4

CLASS

RESPIRATORY
ALLERGIC CONJUNCTIVITIS
H1 HISTAMINE RECEPTOR ANTAGONIST

ROUTE (list)

OPHTHALMIC

PK parameters

Tmax 0.25 HOUR
Cmax 0.195 PICOMOLAR
PPB 39.2 PERCENT

MW 307.39
NB_atoms 23
XLogP 2.78
PSA 34.574
NB_HD 0
NB_HA 4
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
NDA 022134 (label) INN (ALCAFTADINE) LASTACAFT (ABBVIE) APPROVAL= AP YEAR= 2010 NEWMOLECULARENTITY
NDA 210659 (pdf not found) INN (ALCAFTADINE) ALCAFTADINE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 209706 (pdf not found) INN (ALCAFTADINE) ALCAFTADINE (GLAND) APPROVAL= AP YEAR= 2024
NDA 209290 (pdf not found) INN (ALCAFTADINE) ALCAFTADINE (ALEMBIC) APPROVAL= AP YEAR= 2024