e-Drug3D

1514

FIDAXOMICIN

INN
FIDAXOMICIN

cas 873857-62-6

CLASS

ANTIINFECTIVES
MACROLIDE
TREATMENT OF CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA
INHIBITOR RNA SYNTHESIS BY RNA POLYMERASES

ROUTE (list)

ORAL

ATC code

A07AA12

PK parameters

Tmax 2 HOUR
Cmax 4.9 NANOMOLAR (200 MILLIGRAM)
t1/2 11.7 HOUR

Target

TARGET BETA SUBUNIT OF RNA POLYMERASE

PDB
6BZO (MTB RNAP HOLO, RBPA, FIDAXOMICIN, UPSTREAM FORK DNA)

Ligand code = FI8 (link to the list of PDB complexes)

Download experimental 3D coordinates of FI8 with added hydrogens

DrugCentral

DNA-directed RNA polymerase UNIPROT Q182S6 rpoZ

Download SDF file

Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-�-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-�-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-

Formula:
C52H74Cl2O18

Calculated chemical properties:

MW 1058.01
NB_atoms 72
XLogP 6.23
PSA 249.382
NB_HD 7
NB_HA 18
fsp3 0.63
Lipinski(0=no;1=yes) 0

FDA
NDA 201699 (label) INN (FIDAXOMICIN) DIFICID (CUBIST PHARMS LLC) APPROVAL= AP YEAR= 2011 NEWMOLECULARENTITY
NDA 213138 (label) INN (FIDAXOMICIN) DIFICID (CUBIST PHARMS LLC) APPROVAL= AP YEAR= 2020
NDA 208443 (pdf not found) INN (FIDAXOMICIN) FIDAXOMICIN (ACTAVIS LABS FL) APPROVAL= AP YEAR= 2024
NDA 219559 (pdf not found) INN (FIDAXOMICIN) FIDAXOMICIN (APOTEX) APPROVAL= AP YEAR= 2026
NDA 220374 (pdf not found) INN (FIDAXOMICIN) FIDAXOMICIN (TORRENT) APPROVAL= AP YEAR= 2026