1416
METABOLISM
SUPPLEMENT
DECREASED ELEVATED PLASMA AMMONIA GLUTAMINE LEVELS
ANTIHYPERAMMONEMIC
UREA CYCLE DISORDERS
RAPIDLY METABOLIZED TO PHENYLACETATE
NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS)
ORAL
Tmax 1 HOUR
Cmax 1.32 MILLIMOLAR (5 GRAMS)
PPB 89 PERCENT
t1/2 0.77 HOUR
SOLUBLE IN WATER
PDB
3TZ2 (CRYSTAL STRUCTURE OF BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE, PHENYLBUTYRATE COMPLEX)
Ligand code = CLT (link to the list of PDB complexes)
Download experimental 3D coordinates of CLT with added hydrogens
Unknown
Formula:
C10H12O2
Calculated chemical properties:
NB_atoms 12
XLogP 0.76
PSA 35.61
NB_HD 0
NB_HA 2
fsp3 0.30
Lipinski(0=no;1=yes) 1
NDA 020572 (label) INN (SODIUM PHENYLBUTYRATE) BUPHENYL (HORIZON THERAP US) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020573 (label) INN (SODIUM PHENYLBUTYRATE) BUPHENYL (HORIZON THERAP US) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 090910 (pdf not found) INN (SODIUM PHENYLBUTYRATE) SODIUM PHENYLBUTYRATE (ALVOGEN) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 202819 (pdf not found) INN (SODIUM PHENYLBUTYRATE) SODIUM PHENYLBUTYRATE (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203918 (pdf not found) INN (SODIUM PHENYLBUTYRATE) SODIUM PHENYLBUTYRATE (PH HEALTH) APPROVAL= AP YEAR= 2016
NDA 204395 (pdf not found) INN (SODIUM PHENYLBUTYRATE) SODIUM PHENYLBUTYRATE (PH HEALTH) APPROVAL= AP YEAR= 2016
NDA 216513 (label) INN (SODIUM PHENYLBUTYRATE) PHEBURANE (MEDUNIK) APPROVAL= AP YEAR= 2022
NDA 214860 (label) INN (SODIUM PHENYLBUTYRATE) OLPRUVA (ACER) APPROVAL= AP YEAR= 2022
NDA 216462 (pdf not found) INN (SODIUM PHENYLBUTYRATE) SODIUM PHENYLBUTYRATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2022
NDA 216660 (label) INN (SODIUM PHENYLBUTYRATE ; TAURURSODIOL) RELYVRIO (AMYLYX) APPROVAL= AP YEAR= 2022 NEWMOLECULARENTITY DISCONTINUED
NDA 220418 (pdf not found) INN (SODIUM PHENYLBUTYRATE) SODIUM PHENYLBUTYRATE (NAVINTA LLC) APPROVAL= AP YEAR= 2026
1607
NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS)
AMMONIA SCAVENGER
SUBSTRATE METABOLIZED BY PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE
COMPOUND THAT CONJUGATES WITH GLUTAMINE VIA ACETYLATION TO FORM PHENYLACETYLGLUTAMINE
PHENYLACETYLGLUTAMINE THEN IS EXCRETED BY THE KIDNEYS
ON A MOLAR BASIS, IT IS COMPARABLE TO UREA (EACH CONTAINING TWO MOLES OF NITROGEN)
THEREFORE, PHENYLACETYLGLUTAMINE PROVIDES AN ALTERNATE VEHICLE FOR WASTE NITROGEN EXCRETION
-
ATC code
A16AX09
Tmax 3.7 HOUR
Cmax 205.8 MICROMOLAR
PPB 51 PERCENT
t1/2 1.15 HOUR
SOLUBLE IN WATER
PDB
2ISF (CRYSTAL STRUCTURE OF C298A W219Y ALDOSE REDUCTASE COMPLEXED WITH PHENYLACETIC ACID)
Ligand code = PAC (link to the list of PDB complexes)
Download experimental 3D coordinates of PAC with added hydrogens
Unknown
Formula:
C8H8O2
Calculated chemical properties:
NB_atoms 10
XLogP -0.02
PSA 35.691
NB_HD 0
NB_HA 2
fsp3 0.12
Lipinski(0=no;1=yes) 1
-