e-Drug3D
1340
cas 53-36-1
CLASS
DERMATOLOGICALS
GLUCOCORTICOID
CORTICOSTEROIDS
ANTIEMETICS
AGONIST
ANTI-INFLAMMATORY
IMMUNOSUPPRESSANT
ANTI-ALLERGIC
ROUTE (list)
INJECTION TOPICAL RECTAL
ATC code
D07AA01
D10AA02
H02AB04
D07AC14
D07CA02
S01CA08
S03CA07
H02BX01
PK parameters
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET GLUCOCORTICOID RECEPTOR
Glucocorticoid receptor UNIPROT P04150 NR3C1
Formula:
C24H32O6
Calculated chemical properties:
MW 416.50
NB_atoms 30
XLogP 2.37
PSA 90.6
NB_HD 2
NB_HA 6
fsp3 0.71
Lipinski(0=no;1=yes) 1
NB_atoms 30
XLogP 2.37
PSA 90.6
NB_HD 2
NB_HA 6
fsp3 0.71
Lipinski(0=no;1=yes) 1
FDA
NDA 085374 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086507 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086903 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (EPIC PHARMA LLC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087248 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011757 (label) INN (METHYLPREDNISOLONE ACETATE) DEPO-MEDROL (PFIZER) APPROVAL= AP YEAR= 1959
NDA 012421 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) MEDROL ACETATE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 060611 (pdf not found) INN (METHYLPREDNISOLONE ACETATE ; NEOMYCIN SULFATE) NEO-MEDROL ACETATE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 018102 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) MEDROL (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085595 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 085597 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 085600 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 086666 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) M-PREDROL (BEL MAR) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 087135 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) M-PREDROL (BEL MAR) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 040557 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (HONG KONG) APPROVAL= AP YEAR= 2005
NDA 040620 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 040719 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 040794 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 201835 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 210043 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 214297 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (PH HEALTH) APPROVAL= AP YEAR= 2022
NDA 211930 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 214870 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WILSHIRE PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 216502 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (AMNEAL) APPROVAL= AP YEAR= 2023
NDA 219145 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (HIKMA) APPROVAL= AP YEAR= 2025
NDA 220556 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (CAPLIN) APPROVAL= AP YEAR= 2026
NDA 085374 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086507 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086903 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (EPIC PHARMA LLC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087248 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011757 (label) INN (METHYLPREDNISOLONE ACETATE) DEPO-MEDROL (PFIZER) APPROVAL= AP YEAR= 1959
NDA 012421 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) MEDROL ACETATE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 060611 (pdf not found) INN (METHYLPREDNISOLONE ACETATE ; NEOMYCIN SULFATE) NEO-MEDROL ACETATE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 018102 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) MEDROL (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085595 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 085597 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 085600 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 086666 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) M-PREDROL (BEL MAR) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 087135 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) M-PREDROL (BEL MAR) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 040557 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (HONG KONG) APPROVAL= AP YEAR= 2005
NDA 040620 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 040719 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 040794 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 201835 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 210043 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 214297 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (PH HEALTH) APPROVAL= AP YEAR= 2022
NDA 211930 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 214870 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (WILSHIRE PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 216502 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (AMNEAL) APPROVAL= AP YEAR= 2023
NDA 219145 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (HIKMA) APPROVAL= AP YEAR= 2025
NDA 220556 (pdf not found) INN (METHYLPREDNISOLONE ACETATE) METHYLPREDNISOLONE ACETATE (CAPLIN) APPROVAL= AP YEAR= 2026
e-Drug3D
222
cas 83-43-2
CLASS
DERMATOLOGICALS
GLUCOCORTICOID
ANTI-INFLAMMATORY AGENTS
ROUTE (list)
ORAL OPHTHALMIC
ATC code
D07AA01
D10AA02
H02AB04
D07AC14
D07CA02
S01CA08
S03CA07
H02BX01
PK parameters
VD 78 LITER (65 KILOGRAM)
Cl 23.8 LITER / HOUR (65 KILOGRAM)
PPB 77 PERCENT
t1/2 2.3 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET GLUCOCORTICOID RECEPTOR
Glucocorticoid receptor UNIPROT P04150 NR3C1
Formula:
C22H30O5
Calculated chemical properties:
MW 374.46
NB_atoms 27
XLogP 1.80
PSA 85.658
NB_HD 3
NB_HA 5
fsp3 0.73
Lipinski(0=no;1=yes) 1
NB_atoms 27
XLogP 1.80
PSA 85.658
NB_HD 3
NB_HA 5
fsp3 0.73
Lipinski(0=no;1=yes) 1
FDA
NDA 060645 (pdf not found) INN (METHYLPREDNISOLONE ; NEOMYCIN SULFATE) NEO-MEDROL (PHARMACIA AND UPJOHN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085650 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (HEATHER) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011153 (label) INN (METHYLPREDNISOLONE) MEDROL (PFIZER) APPROVAL= AP YEAR= 1957 NEWMOLECULARENTITY
NDA 087341 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (RISING) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 086159 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086161 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088497 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 089207 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PAR PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089208 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PAR PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089209 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PAR PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 040189 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (JUBILANT CADISTA) APPROVAL= AP YEAR= 1997
NDA 040194 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (SANDOZ) APPROVAL= AP YEAR= 1997
NDA 040232 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (WATSON LABS) APPROVAL= AP YEAR= 1997
NDA 040183 (label) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PH HEALTH) APPROVAL= AP YEAR= 1998
NDA 204072 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (TIANJIN TIANYAO) APPROVAL= AP YEAR= 2018
NDA 206751 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 209097 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (CHARTWELL RX) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210985 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212262 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PRAXGEN) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 207481 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (AMNEAL) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 060645 (pdf not found) INN (METHYLPREDNISOLONE ; NEOMYCIN SULFATE) NEO-MEDROL (PHARMACIA AND UPJOHN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085650 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (HEATHER) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011153 (label) INN (METHYLPREDNISOLONE) MEDROL (PFIZER) APPROVAL= AP YEAR= 1957 NEWMOLECULARENTITY
NDA 087341 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (RISING) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 086159 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086161 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088497 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 089207 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PAR PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089208 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PAR PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089209 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PAR PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 040189 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (JUBILANT CADISTA) APPROVAL= AP YEAR= 1997
NDA 040194 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (SANDOZ) APPROVAL= AP YEAR= 1997
NDA 040232 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (WATSON LABS) APPROVAL= AP YEAR= 1997
NDA 040183 (label) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PH HEALTH) APPROVAL= AP YEAR= 1998
NDA 204072 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (TIANJIN TIANYAO) APPROVAL= AP YEAR= 2018
NDA 206751 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 209097 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (CHARTWELL RX) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210985 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212262 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (PRAXGEN) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 207481 (pdf not found) INN (METHYLPREDNISOLONE) METHYLPREDNISOLONE (AMNEAL) APPROVAL= AP YEAR= 2021 DISCONTINUED