e-Drug3D
129
cas 57-41-0
CLASS
NERVOUS SYSTEM
ANTIEPILEPTIC
ANTICONVULSANT
ROUTE (list)
ORAL INJECTION
PK parameters
Tmax 1.5 HOUR
PPB 88 PERCENT
t1/2 22 HOUR
TARGET VOLTAGE-DEPENDENT SODIUM CHANNEL
Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A
Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A
Formula:
C15H12N2O2
Calculated chemical properties:
MW 252.27
NB_atoms 19
XLogP 1.77
PSA 56.912
NB_HD 2
NB_HA 4
fsp3 0.07
Lipinski(0=no;1=yes) 1
NB_atoms 19
XLogP 1.77
PSA 56.912
NB_HD 2
NB_HA 4
fsp3 0.07
Lipinski(0=no;1=yes) 1
FDA
NDA 085434 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088519 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088520 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (SOLOPAK) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088521 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088711 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTEX (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089900 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008762 (label) INN (PHENYTOIN) DILANTIN-125 (VIATRIS) APPROVAL= AP YEAR= 1953
NDA 010151 (label) INN (PHENYTOIN SODIUM) DILANTIN (PARKE DAVIS) APPROVAL= AP YEAR= 1956 DISCONTINUED
NDA 084307 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (HIKMA) APPROVAL= AP YEAR= 1975
NDA 080857 (pdf not found) INN (PHENYTOIN SODIUM) DIPHENYLAN SODIUM (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084349 (label) INN (PHENYTOIN SODIUM) DILANTIN (VIATRIS) APPROVAL= AP YEAR= 1976
NDA 085435 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (PHARMERAL) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 080259 (pdf not found) INN (PHENYTOIN SODIUM) PROMPT PHENYTOIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 080905 (pdf not found) INN (PHENYTOIN SODIUM) PROMPT PHENYTOIN SODIUM (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 084427 (label) INN (PHENYTOIN) DILANTIN (PHARMACIA) APPROVAL= AP YEAR= 1979
NDA 085894 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 089003 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089441 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089501 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (MARSAM PHARMS LLC) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089521 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089744 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089779 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (MARSAM PHARMS LLC) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 089892 (pdf not found) INN (PHENYTOIN) PHENYTOIN (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 040298 (label) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (MYLAN) APPROVAL= AP YEAR= 1998
NDA 040342 (pdf not found) INN (PHENYTOIN) PHENYTOIN (VISTAPHARM LLC) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 040420 (pdf not found) INN (PHENYTOIN) PHENYTOIN (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 040435 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 040521 (pdf not found) INN (PHENYTOIN) PHENYTOIN (TARO) APPROVAL= AP YEAR= 2004
NDA 040610 (pdf not found) INN (PHENYTOIN) PHENYTOIN (VISTAPHARM) APPROVAL= AP YEAR= 2005 OBSOLETE
NDA 040573 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (ACELLA) APPROVAL= AP YEAR= 2006
NDA 040621 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (SUN PHARM INDS (IN)) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 040684 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (TARO) APPROVAL= AP YEAR= 2006
NDA 040759 (label) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (WOCKHARDT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040781 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (AM REGENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040731 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (SUN PHARM INDS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 040732 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 040765 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (AMNEAL PHARMS NY) APPROVAL= AP YEAR= 2008
NDA 200691 (pdf not found) INN (PHENYTOIN) PHENYTOIN (RISING) APPROVAL= AP YEAR= 2012
NDA 040884 (pdf not found) INN (PHENYTOIN) PHENYTOIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2014
NDA 200565 (pdf not found) INN (PHENYTOIN) PHENYTOIN (TARO) APPROVAL= AP YEAR= 2014
NDA 204309 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2015
NDA 211633 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (LUPIN) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 213834 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (UNICHEM) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 219773 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (MANKIND PHARMA) APPROVAL= AP YEAR= 2026
NDA 085434 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088519 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088520 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (SOLOPAK) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088521 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088711 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTEX (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089900 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008762 (label) INN (PHENYTOIN) DILANTIN-125 (VIATRIS) APPROVAL= AP YEAR= 1953
NDA 010151 (label) INN (PHENYTOIN SODIUM) DILANTIN (PARKE DAVIS) APPROVAL= AP YEAR= 1956 DISCONTINUED
NDA 084307 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (HIKMA) APPROVAL= AP YEAR= 1975
NDA 080857 (pdf not found) INN (PHENYTOIN SODIUM) DIPHENYLAN SODIUM (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084349 (label) INN (PHENYTOIN SODIUM) DILANTIN (VIATRIS) APPROVAL= AP YEAR= 1976
NDA 085435 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (PHARMERAL) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 080259 (pdf not found) INN (PHENYTOIN SODIUM) PROMPT PHENYTOIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 080905 (pdf not found) INN (PHENYTOIN SODIUM) PROMPT PHENYTOIN SODIUM (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 084427 (label) INN (PHENYTOIN) DILANTIN (PHARMACIA) APPROVAL= AP YEAR= 1979
NDA 085894 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 089003 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089441 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089501 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (MARSAM PHARMS LLC) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089521 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089744 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089779 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (MARSAM PHARMS LLC) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 089892 (pdf not found) INN (PHENYTOIN) PHENYTOIN (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 040298 (label) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (MYLAN) APPROVAL= AP YEAR= 1998
NDA 040342 (pdf not found) INN (PHENYTOIN) PHENYTOIN (VISTAPHARM LLC) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 040420 (pdf not found) INN (PHENYTOIN) PHENYTOIN (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 040435 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 040521 (pdf not found) INN (PHENYTOIN) PHENYTOIN (TARO) APPROVAL= AP YEAR= 2004
NDA 040610 (pdf not found) INN (PHENYTOIN) PHENYTOIN (VISTAPHARM) APPROVAL= AP YEAR= 2005 OBSOLETE
NDA 040573 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (ACELLA) APPROVAL= AP YEAR= 2006
NDA 040621 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (SUN PHARM INDS (IN)) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 040684 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (TARO) APPROVAL= AP YEAR= 2006
NDA 040759 (label) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (WOCKHARDT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040781 (pdf not found) INN (PHENYTOIN SODIUM) PHENYTOIN SODIUM (AM REGENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040731 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (SUN PHARM INDS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 040732 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 040765 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (AMNEAL PHARMS NY) APPROVAL= AP YEAR= 2008
NDA 200691 (pdf not found) INN (PHENYTOIN) PHENYTOIN (RISING) APPROVAL= AP YEAR= 2012
NDA 040884 (pdf not found) INN (PHENYTOIN) PHENYTOIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2014
NDA 200565 (pdf not found) INN (PHENYTOIN) PHENYTOIN (TARO) APPROVAL= AP YEAR= 2014
NDA 204309 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2015
NDA 211633 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (LUPIN) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 213834 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (UNICHEM) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 219773 (pdf not found) INN (PHENYTOIN SODIUM) EXTENDED PHENYTOIN SODIUM (MANKIND PHARMA) APPROVAL= AP YEAR= 2026
e-Drug3D
734
cas 93390-81-9
CLASS
NERVOUS SYSTEM
ANTIEPILEPTIC
ANTICONVULSANTS
ROUTE (list)
INJECTION INTRAVENOUS
ATC code
N03AB05
PK parameters
Tmax 0.25 HOUR
VD 7.5 LITER
PPB 97 PERCENT
t1/2 0.25 HOUR
TARGET VOLTAGE-DEPENDENT SODIUM CHANNEL
Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A
Formula:
C16H15N2O6P
Calculated chemical properties:
MW 360.25
NB_atoms 25
XLogP 0.28
PSA 113.114
NB_HD 1
NB_HA 8
fsp3 0.12
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 0.28
PSA 113.114
NB_HD 1
NB_HA 8
fsp3 0.12
Lipinski(0=no;1=yes) 1
FDA
NDA 020450 (label) INN (FOSPHENYTOIN SODIUM) CEREBYX (PARKE DAVIS) APPROVAL= AP YEAR= 1996
NDA 076886 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (DR REDDYS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077481 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HIKMA) APPROVAL= AP YEAR= 2007
NDA 077989 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HIKMA) APPROVAL= AP YEAR= 2007
NDA 078052 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007
NDA 078126 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (APOTEX INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078137 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2007
NDA 078158 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HOSPIRA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078277 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (AM REGENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078417 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2008
NDA 078476 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (AMNEAL) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078765 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2009
NDA 078736 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090099 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (AM REGENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 210864 (label) INN (FOSPHENYTOIN SODIUM) SESQUIENT (LUPIN) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214926 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (GLAND) APPROVAL= AP YEAR= 2023
NDA 020450 (label) INN (FOSPHENYTOIN SODIUM) CEREBYX (PARKE DAVIS) APPROVAL= AP YEAR= 1996
NDA 076886 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (DR REDDYS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077481 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HIKMA) APPROVAL= AP YEAR= 2007
NDA 077989 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HIKMA) APPROVAL= AP YEAR= 2007
NDA 078052 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007
NDA 078126 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (APOTEX INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078137 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2007
NDA 078158 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HOSPIRA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078277 (label) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (AM REGENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078417 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2008
NDA 078476 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (AMNEAL) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078765 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2009
NDA 078736 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090099 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (AM REGENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 210864 (label) INN (FOSPHENYTOIN SODIUM) SESQUIENT (LUPIN) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214926 (pdf not found) INN (FOSPHENYTOIN SODIUM) FOSPHENYTOIN SODIUM (GLAND) APPROVAL= AP YEAR= 2023