e-Drug3D

1207

cas 51-41-2

CLASS

CARDIOVASCULAR
ADRENERGIC RECEPTOR AGONIST
SYMPATHOMIMETICS
VASOCONSTRICTOR AGENTS
PERIPHERAL VASOCONSTRICTOR (ALPHA-ADRENERGIC ACTION) AND AS AN INOTROPIC STIMULATOR OF THE HEART AND DILATOR OF CORONARY ARTERIES (BETA-ADRENERGIC ACTION)

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

TARGET ADRENERGIC RECEPTORS

PDB
3HCD (CRYSTAL STRUCTURE OF HPNMT IN COMPLEX WITH NORADRENALINE AND ADOHCY)

Ligand code = LNR (link to the list of PDB complexes)

Download experimental 3D coordinates of LNR with added hydrogens

MW 169.18
NB_atoms 12
XLogP 0.09
PSA 87.389
NB_HD 5
NB_HA 4
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 007513 (label) INN (NOREPINEPHRINE BITARTRATE) LEVOPHED (HOSPIRA) APPROVAL= AP YEAR= 1950 NEWMOLECULARENTITY
NDA 008592 (pdf not found) INN (NOREPINEPHRINE BITARTRATE ; PROCAINE HYDROCHLORIDE ; PROPOXYCAINE HYDROCHLORIDE) RAVOCAINE AND NOVOCAIN W/ LEVOPHED (EASTMAN KODAK) APPROVAL= AP YEAR= 1952 DISCONTINUED
NDA 040455 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (MEITHEAL) APPROVAL= AP YEAR= 2003
NDA 040462 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 040522 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (METRICS PHARM) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 040859 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2012
NDA 203662 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (HIKMA) APPROVAL= AP YEAR= 2018
NDA 210839 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (AMNEAL) APPROVAL= AP YEAR= 2018
NDA 211242 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2018
NDA 211359 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (SANDOZ) APPROVAL= AP YEAR= 2018
NDA 211382 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2020
NDA 211980 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (SUN PHARM) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 214313 (label) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2021
NDA 214323 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (GLAND) APPROVAL= AP YEAR= 2021
NDA 214455 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (BRECKENRIDGE) APPROVAL= AP YEAR= 2021
NDA 214628 (label) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE IN 0.9% SODIUM CHLORIDE (LONG GROVE PHARMS) APPROVAL= AP YEAR= 2022
NDA 215700 (label) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE IN 0.9% SODIUM CHLORIDE (INFORLIFE) APPROVAL= AP YEAR= 2022
NDA 216341 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 217575 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (CAPLIN) APPROVAL= AP YEAR= 2023
NDA 218758 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (RISING) APPROVAL= AP YEAR= 2024
NDA 219163 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (ASPIRO) APPROVAL= AP YEAR= 2025
NDA 219443 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (BIOCON PHARMA) APPROVAL= AP YEAR= 2025
NDA 219692 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE (SAGENT) APPROVAL= AP YEAR= 2025
NDA 218595 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (MSN) APPROVAL= AP YEAR= 2025
NDA 219924 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (ANTHEA PHARMA) APPROVAL= AP YEAR= 2025
NDA 216272 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE (NEPHRON) APPROVAL= AP YEAR= 2026
NDA 220483 (pdf not found) INN (NOREPINEPHRINE BITARTRATE) NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE (SAGENT) APPROVAL= AP YEAR= 2026

e-Drug3D

1722

cas 23651-95-8

CLASS

CARDIOVASCULAR
TREATMENT OF ORTHOSTATIC DIZZINESS AND LIGHTHEADEDNESS
SYNTHETIC AMINO ACID PRECURSOR OF NOREPINEPHRINE
SUBSTRATE OF DOPA-DECARBOXYLASE

ROUTE (list)

ORAL

PK parameters

Tmax 2 HOUR
VD 200 LITER
Cl 55.4 LITER / HOUR (EQN)
PPB 75 PERCENT
t1/2 2.5 HOUR

MW 212.18
NB_atoms 15
XLogP -1.79
PSA 117.983
NB_HD 5
NB_HA 6
fsp3 0.22
Lipinski(0=no;1=yes) 1

FDA
NDA 203202 (label) INN (DROXIDOPA) NORTHERA (LUNDBECK NA LTD) APPROVAL= AP YEAR= 2014
NDA 211818 (pdf not found) INN (DROXIDOPA) DROXIDOPA (ZYDUS PHARMS) APPROVAL= AP YEAR= 2021
NDA 211652 (pdf not found) INN (DROXIDOPA) DROXIDOPA (LUPIN PHARMS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211726 (pdf not found) INN (DROXIDOPA) DROXIDOPA (ANNORA) APPROVAL= AP YEAR= 2021
NDA 211741 (pdf not found) INN (DROXIDOPA) DROXIDOPA (MSN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 212835 (pdf not found) INN (DROXIDOPA) DROXIDOPA (HIKMA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213033 (pdf not found) INN (DROXIDOPA) DROXIDOPA (BIONPHARMA) APPROVAL= AP YEAR= 2021
NDA 213162 (pdf not found) INN (DROXIDOPA) DROXIDOPA (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213661 (pdf not found) INN (DROXIDOPA) DROXIDOPA (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213911 (pdf not found) INN (DROXIDOPA) DROXIDOPA (ALKEM LABS LTD) APPROVAL= AP YEAR= 2021
NDA 214017 (pdf not found) INN (DROXIDOPA) DROXIDOPA (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2021
NDA 214384 (pdf not found) INN (DROXIDOPA) DROXIDOPA (SUN PHARM) APPROVAL= AP YEAR= 2021
NDA 214387 (pdf not found) INN (DROXIDOPA) DROXIDOPA (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2021
NDA 214391 (pdf not found) INN (DROXIDOPA) DROXIDOPA (JUBILANT CADISTA) APPROVAL= AP YEAR= 2021
NDA 214543 (pdf not found) INN (DROXIDOPA) DROXIDOPA (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2021
NDA 215265 (pdf not found) INN (DROXIDOPA) DROXIDOPA (ADAPTIS) APPROVAL= AP YEAR= 2021
NDA 214217 (pdf not found) INN (DROXIDOPA) DROXIDOPA (CHARTWELL RX) APPROVAL= AP YEAR= 2022 DISCONTINUED

e-Drug3D

1817

cas 299-42-3

CLASS

RESPIRATORY
SYMPATHOMIMETIC
ALPHA AND BETA ADRENERGIC AGONIST
NOREPINEPHRINE RELEASING AGENT
TREATMENT OF CLINICALLY IMPORTANT HYPOTENSION OCCURRING IN THE SETTING OF ANESTHESIA
METABOLIZED INTO NOREPHEDRINE

ROUTE (list)

INTRAVENOUS

PK parameters

t1/2 6 HOUR

MW 165.23
NB_atoms 12
XLogP 1.33
PSA 32.155
NB_HD 2
NB_HA 2
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 208289 (label) INN (EPHEDRINE SULFATE) AKOVAZ (EXELA PHARMA) APPROVAL= AP YEAR= 2016
NDA 208609 (label) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (RENEW PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208943 (label) INN (EPHEDRINE SULFATE) CORPHEDRA (PH HEALTH) APPROVAL= AP YEAR= 2017
NDA 209784 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (SANDOZ) APPROVAL= AP YEAR= 2017
NDA 212932 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 213407 (label) INN (EPHEDRINE SULFATE) EMERPHED (NEXUS) APPROVAL= AP YEAR= 2020
NDA 209646 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2020
NDA 212649 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (DR REDDYS) APPROVAL= AP YEAR= 2020
NDA 213994 (label) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (PH HEALTH) APPROVAL= AP YEAR= 2020
NDA 214334 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (HIKMA) APPROVAL= AP YEAR= 2020
NDA 213536 (label) INN (EPHEDRINE HYDROCHLORIDE) REZIPRES (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 214579 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2021
NDA 215825 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (XIROMED) APPROVAL= AP YEAR= 2022
NDA 216129 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 216146 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (GLAND) APPROVAL= AP YEAR= 2022
NDA 214528 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 217276 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217721 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (HIKMA) APPROVAL= AP YEAR= 2024
NDA 219050 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (CAPLIN) APPROVAL= AP YEAR= 2024
NDA 218211 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (GLAND) APPROVAL= AP YEAR= 2025
NDA 218271 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2025
NDA 215593 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (CIVICA) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 216740 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2026
NDA 219991 (pdf not found) INN (EPHEDRINE SULFATE) EPHEDRINE SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2026