e-Drug3D

1072

cas 24280-93-1

CLASS

IMMUNOMODULATING AGENT
IMMUNOSUPPRESSANTS
INHIBITOR OF GUANOSINE NUCLEOTIDE SYNTHESIS
PREVENTION OF ORGAN REJECTION

ROUTE (list)

ORAL

PK parameters

F 93 PERCENT
VD 112 LITER
Cl 8.4 LITER / HOUR
PPB 98 PERCENT
t1/2 12 HOUR

TARGET INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH)

PDB
4FXS (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE FROM VIBRIO CHOLERAE COMPLEXED WITH IMP AND MYCOPHENOLIC ACID)

Ligand code = MOA (link to the list of PDB complexes)

Download experimental 3D coordinates of MOA with added hydrogens

MW 319.32
NB_atoms 23
XLogP 1.40
PSA 94.744
NB_HD 1
NB_HA 6
fsp3 0.41
Lipinski(0=no;1=yes) 1

FDA
NDA 050791 (label) INN (MYCOPHENOLIC ACID) MYFORTIC (NOVARTIS) APPROVAL= AP YEAR= 2004
NDA 091558 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (APOTEX INC) APPROVAL= AP YEAR= 2012
NDA 091248 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (RK PHARMA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202720 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202555 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 211173 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (CONCORD BIOTECH LTD) APPROVAL= AP YEAR= 2019
NDA 214376 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2021
NDA 208315 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (ALKEM LABS LTD) APPROVAL= AP YEAR= 2021
NDA 214289 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (TWI PHARMS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 214630 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (BIOCON PHARMA) APPROVAL= AP YEAR= 2021
NDA 217031 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (BIOCON PHARMA) APPROVAL= AP YEAR= 2023
NDA 216637 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (FOSUN WANBANG) APPROVAL= AP YEAR= 2024
NDA 218603 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024

e-Drug3D

1066

cas 128794-94-5

CLASS

IMMUNOSUPPRESSANTS
IMMUNOMODULATING AGENT
IMMUNOSUPPRESSIVE AGENTS
INHIBITOR OF GUANOSINE NUCLEOTIDE SYNTHESIS
PREVENTION OF ORGAN REJECTION

ROUTE (list)

ORAL INJECTION

PK parameters

F 94 PERCENT

MW 433.49
NB_atoms 31
XLogP 2.52
PSA 98.564
NB_HD 1
NB_HA 8
fsp3 0.57
Lipinski(0=no;1=yes) 1

FDA
NDA 050722 (label) INN (MYCOPHENOLATE MOFETIL) CELLCEPT (ROCHE PALO) APPROVAL= AP YEAR= 1995
NDA 050723 (label) INN (MYCOPHENOLATE MOFETIL) CELLCEPT (ROCHE PALO) APPROVAL= AP YEAR= 1997
NDA 050758 (label) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) CELLCEPT (ROCHE PALO) APPROVAL= AP YEAR= 1998
NDA 050759 (label) INN (MYCOPHENOLATE MOFETIL) CELLCEPT (ROCHE PALO) APPROVAL= AP YEAR= 1998
NDA 065410 (label) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065413 (label) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065379 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 065451 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 065416 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2009
NDA 065433 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065457 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065477 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065491 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (TEVA PHARMS) APPROVAL= AP YEAR= 2009
NDA 065520 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (MYLAN) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065521 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (MYLAN) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090111 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090253 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2009
NDA 090419 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (APOTEX CORP) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090499 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (APOTEX) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090055 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (STRIDES PHARMA) APPROVAL= AP YEAR= 2010
NDA 090311 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (BEDFORD LABS) APPROVAL= TA YEAR= 2010
NDA 090456 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (STRIDES PHARMA) APPROVAL= AP YEAR= 2010
NDA 090464 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090606 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (AMNEAL) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091249 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ALKEM LABS LTD) APPROVAL= AP YEAR= 2011
NDA 091315 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200197 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ALKEM LABS LTD) APPROVAL= AP YEAR= 2013
NDA 090661 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (JUBILANT CADISTA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 090762 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (JUBILANT CADISTA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203005 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ALKEM LABS LTD) APPROVAL= AP YEAR= 2014
NDA 203575 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2016
NDA 203859 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017
NDA 204043 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2017
NDA 204076 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ZHEJIANG HISUN PHARM) APPROVAL= AP YEAR= 2017
NDA 204077 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (ZHEJIANG HISUN PHARM) APPROVAL= AP YEAR= 2017
NDA 204473 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 210181 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (CONCORD BIOTECH LTD) APPROVAL= AP YEAR= 2019
NDA 210370 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (VISTAPHARM LLC) APPROVAL= AP YEAR= 2019
NDA 212087 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (CONCORD BIOTECH LTD) APPROVAL= AP YEAR= 2020
NDA 211374 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 212130 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2021
NDA 214525 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (LANNETT CO INC) APPROVAL= AP YEAR= 2021
NDA 214871 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (AMNEAL) APPROVAL= AP YEAR= 2021
NDA 211272 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 216390 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2022
NDA 214283 (pdf not found) INN (MYCOPHENOLATE MOFETIL HYDROCHLORIDE) MYCOPHENOLATE MOFETIL HYDROCHLORIDE (BPI LABS) APPROVAL= AP YEAR= 2023
NDA 212634 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2023
NDA 213955 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (RISING) APPROVAL= AP YEAR= 2023
NDA 216482 (label) INN (MYCOPHENOLATE MOFETIL) MYHIBBIN (AZURITY) APPROVAL= AP YEAR= 2024
NDA 217828 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 217937 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024
NDA 207022 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (HETERO LABS LTD V) APPROVAL= AP YEAR= 2024
NDA 208119 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (HETERO LABS LTD V) APPROVAL= AP YEAR= 2024
NDA 214079 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (WUXI) APPROVAL= AP YEAR= 2024
NDA 218227 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 218566 (pdf not found) INN (MYCOPHENOLATE MOFETIL) MYCOPHENOLATE MOFETIL (CONCORD BIOTECH LTD) APPROVAL= AP YEAR= 2026